Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue in nontransgenic controls

Jaroslava Trnovská; Jan Šilhavý; Ondřej Kuda; Vladimír Landa; Václav Zídek; Petr Mlejnek; Miroslava Šimáková; Hynek Strnad; Vojtěch Škop; Olena Oliyarnyk; Ludmila Kazdová; Martin Haluzík; Michal Pravenec

doi:10.1371/journal.pone.0179063

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Peer-reviewed

Research Article

Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue in nontransgenic controls

Jaroslava Trnovská,

Affiliation Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
⨯
Jan Šilhavý,

Affiliation Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
⨯
Ondřej Kuda,

Affiliation Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
⨯
Vladimír Landa,

Affiliation Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
⨯
Václav Zídek,

Affiliation Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
⨯
Petr Mlejnek,

Affiliation Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
⨯
Miroslava Šimáková,

Affiliation Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
⨯
Hynek Strnad,

Affiliation Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic
⨯
Vojtěch Škop,

Affiliation Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
⨯
Olena Oliyarnyk,

Affiliation Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
⨯
Ludmila Kazdová,

Affiliation Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
⨯
Martin Haluzík,

Affiliations Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czech Republic
⨯
Michal Pravenec

* E-mail: pravenec@biomed.cas.cz

Affiliation Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic

http://orcid.org/0000-0001-9197-5871

⨯

Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue in nontransgenic controls

Jaroslava Trnovská,
Jan Šilhavý,
Ondřej Kuda,
Vladimír Landa,
Václav Zídek,
Petr Mlejnek,
Miroslava Šimáková,
Hynek Strnad,
Vojtěch Škop,
Olena Oliyarnyk

Published: June 6, 2017
https://doi.org/10.1371/journal.pone.0179063

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Inflammation
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Brown adipose tissue
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Glucose
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Gene expression
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Oxidation
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Adipose tissue
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Oxidative stress
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C-reactive proteins
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