Differential stability of therapeutic peptides with different proteolytic cleavage sites in blood, plasma and serum

Open Access

Peer-reviewed

Research Article

Roland Böttger,

Affiliations Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, Universität Leipzig, Leipzig, Germany, Center for Biotechnology and Biomedicine, Universität Leipzig, Leipzig, Germany
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Ralf Hoffmann ,

* E-mail: daniel.knappe@bbz.uni-leipzig.de (DK); bioanaly@bbz.uni-leipzig.de (RH)

Affiliations Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, Universität Leipzig, Leipzig, Germany, Center for Biotechnology and Biomedicine, Universität Leipzig, Leipzig, Germany
⨯
Daniel Knappe

* E-mail: daniel.knappe@bbz.uni-leipzig.de (DK); bioanaly@bbz.uni-leipzig.de (RH)

Affiliations Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, Universität Leipzig, Leipzig, Germany, Center for Biotechnology and Biomedicine, Universität Leipzig, Leipzig, Germany

http://orcid.org/0000-0002-4661-8979

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Blood plasma
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Blood
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Metabolites
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Proteases
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Heparin
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Thrombin
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Elimination half-life calculation
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Centrifugation
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