Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer

Carmela De Marco; Carmelo Laudanna; Nicola Rinaldo; Duarte Mendes Oliveira; Maria Ravo; Alessandro Weisz; Michele Ceccarelli; Elvira Caira; Antonia Rizzuto; Pietro Zoppoli; Donatella Malanga; Giuseppe Viglietto

doi:10.1371/journal.pone.0178865

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Peer-reviewed

Research Article

Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer

Carmela De Marco,

Affiliation Dipartimento di Medicina Sperimentale e Clinica, Università “Magna Graecia”, Catanzaro, Italia
⨯
Carmelo Laudanna,

Affiliation Dipartimento di Medicina Sperimentale e Clinica, Università “Magna Graecia”, Catanzaro, Italia
⨯
Nicola Rinaldo,

Affiliation Biogem scarl, Instituto di Rihe Genetiche “Gaetano Salvatore”, Ariano Irpino, Italia
⨯
Duarte Mendes Oliveira,

Affiliation Dipartimento di Medicina Sperimentale e Clinica, Università “Magna Graecia”, Catanzaro, Italia
⨯
Maria Ravo,

Affiliation Laboratorio di Medicina Molecolare e Genomica, Facoltà di Medicina e Chirurgia, Università di Salerno, Baronissi, Italia
⨯
Alessandro Weisz,

Affiliation Laboratorio di Medicina Molecolare e Genomica, Facoltà di Medicina e Chirurgia, Università di Salerno, Baronissi, Italia
⨯
Michele Ceccarelli,

Affiliation Dipartimento di Studi Biologici e Ambientali, Università del Sannio, Benevento, Italia
⨯
Elvira Caira,

Affiliation Dipartimento di Medicina Sperimentale e Clinica, Università “Magna Graecia”, Catanzaro, Italia
⨯
Antonia Rizzuto,

Affiliation Dipartimento di Scienze Mediche e Chirurgiche, Università “Magna Graecia”, Catanzaro, Italia
⨯
Pietro Zoppoli ,

* E-mail: viglietto@unicz.it (GV); zoppoli.pietro@gmail.com (PZ)

Affiliation Dipartimento di Medicina Sperimentale e Clinica, Università “Magna Graecia”, Catanzaro, Italia
⨯
Donatella Malanga,

Affiliation Dipartimento di Medicina Sperimentale e Clinica, Università “Magna Graecia”, Catanzaro, Italia
⨯
Giuseppe Viglietto

Affiliations Dipartimento di Medicina Sperimentale e Clinica, Università “Magna Graecia”, Catanzaro, Italia, Biogem scarl, Instituto di Rihe Genetiche “Gaetano Salvatore”, Ariano Irpino, Italia
⨯

Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer

Carmela De Marco,
Carmelo Laudanna,
Nicola Rinaldo,
Duarte Mendes Oliveira,
Maria Ravo,
Alessandro Weisz,
Michele Ceccarelli,
Elvira Caira,
Antonia Rizzuto,
Pietro Zoppoli

Published: June 29, 2017
https://doi.org/10.1371/journal.pone.0178865

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Non-small cell lung cancer
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Gene expression
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Epithelial cells
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Lung and intrathoracic tumors
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Gene regulation
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Cell proliferation
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Transcription factors
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