Designing small molecules to target cryptic pockets yields both positive and negative allosteric modulators

• Kathryn M. Hart,

  Affiliation Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, United States of America

  http://orcid.org/0000-0002-5277-8872

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• Katelyn E. Moeder,

  Affiliation Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Chris M. W. Ho,

  Affiliation Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Maxwell I. Zimmerman,

  Affiliation Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Thomas E. Frederick,

  Affiliation Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Gregory R. Bowman

  * E-mail: bowman@biochem.wustl.edu

  Affiliations Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Biomedical Engineering, and Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, Missouri, United States of America

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