Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease

Anna Manko; Jean-Paul Motta; James A. Cotton; Troy Feener; Ayodele Oyeyemi; Bruce A. Vallance; John L. Wallace; Andre G. Buret

doi:10.1371/journal.pone.0178647

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Open Access

Peer-reviewed

Research Article

Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease

Anna Manko,

Affiliations Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada, Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada, Host-Parasite Interactions, University of Calgary, Calgary, Alberta, Canada
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Jean-Paul Motta,

Affiliations Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada, Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada, Host-Parasite Interactions, University of Calgary, Calgary, Alberta, Canada
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James A. Cotton,

Affiliations Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada, Host-Parasite Interactions, University of Calgary, Calgary, Alberta, Canada
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Troy Feener,

Affiliations Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada, Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada
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Ayodele Oyeyemi,

Affiliations Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada, Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada, Host-Parasite Interactions, University of Calgary, Calgary, Alberta, Canada
⨯
Bruce A. Vallance,

Affiliation Department of Pediatrics, Division of Gastroenterology, Child and Family Research Institute, Vancouver, British Columbia, Canada
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John L. Wallace,

Affiliations Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada, Department of Physiology & Pharmacology, University of Calgary, Alberta, Canada
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Andre G. Buret

* E-mail: aburet@ucalgary.ca

Affiliations Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada, Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada, Host-Parasite Interactions, University of Calgary, Calgary, Alberta, Canada

http://orcid.org/0000-0002-1205-5936

⨯

Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease

Anna Manko,
Jean-Paul Motta,
James A. Cotton,
Troy Feener,
Ayodele Oyeyemi,
Bruce A. Vallance,
John L. Wallace,
Andre G. Buret

Published: June 16, 2017
https://doi.org/10.1371/journal.pone.0178647

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Giardia
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Colon
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Co-infections
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Trophozoites
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Gastrointestinal tract
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Cysteine proteases
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Parasitic intestinal diseases
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