Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells

Aishwarya G. Nadadhur; Javier Emperador Melero; Marieke Meijer; Desiree Schut; Gerbren Jacobs; Ka Wan Li; J. J. Johannes Hjorth; Rhiannon M. Meredith; Ruud F. Toonen; Ronald E. Van Kesteren; August B. Smit; Matthijs Verhage; Vivi M. Heine

doi:10.1371/journal.pone.0178533

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Peer-reviewed

Research Article

Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells

Aishwarya G. Nadadhur,

Affiliation Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, The Netherlands
⨯
Javier Emperador Melero,

Affiliation Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, The Netherlands
⨯
Marieke Meijer,

Affiliation Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, The Netherlands
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Desiree Schut,

Affiliation Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, The Netherlands
⨯
Gerbren Jacobs,

Affiliation Department of Pediatrics / Child Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands
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Ka Wan Li,

Affiliation Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, The Netherlands
⨯
J. J. Johannes Hjorth,

Current address: Science for Life Laboratory, School of Computer Science and Communication, KTH Royal Institute of Technology, Solna, Sweden

Affiliation Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, The Netherlands
⨯
Rhiannon M. Meredith,

Affiliation Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, The Netherlands
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Ruud F. Toonen,

Affiliation Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, The Netherlands
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Ronald E. Van Kesteren,

Affiliation Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, The Netherlands
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August B. Smit,

Affiliation Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, The Netherlands
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Matthijs Verhage,

Affiliations Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, The Netherlands, Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands
⨯
Vivi M. Heine

* E-mail: vm.heine@vumc.nl

Affiliations Department of Pediatrics / Child Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands, Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, The Netherlands

http://orcid.org/0000-0003-4416-3875

⨯

Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells

Aishwarya G. Nadadhur,
Javier Emperador Melero,
Marieke Meijer,
Desiree Schut,
Gerbren Jacobs,
Ka Wan Li,
J. J. Johannes Hjorth,
Rhiannon M. Meredith,
Ruud F. Toonen,
Ronald E. Van Kesteren

Published: June 6, 2017
https://doi.org/10.1371/journal.pone.0178533

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