The MTH1 inhibitor TH588 demonstrates anti-tumoral effects alone and in combination with everolimus, 5-FU and gamma-irradiation in neuroendocrine tumor cells

Elke Tatjana Aristizabal Prada; Michael Orth; Svenja Nölting; Gerald Spöttl; Julian Maurer; Christoph Auernhammer

doi:10.1371/journal.pone.0178375

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Peer-reviewed

Research Article

The MTH1 inhibitor TH588 demonstrates anti-tumoral effects alone and in combination with everolimus, 5-FU and gamma-irradiation in neuroendocrine tumor cells

Elke Tatjana Aristizabal Prada,

Affiliation Department of Internal Medicine II, Campus Grosshadern, Interdisciplinary Center of Neuroendocrine Tumours of the GastroEnteroPancreatic System (GEPNET-KUM), University-Hospital, Ludwig-Maximilians-University of Munich, Bavaria, Germany
⨯
Michael Orth,

Affiliation Department of Radiation Oncology, Campus Grosshadern, Ludwig-Maximilians-University Munich, Bavaria, Germany
⨯
Svenja Nölting,

Affiliation Department of Internal Medicine II, Campus Grosshadern, Interdisciplinary Center of Neuroendocrine Tumours of the GastroEnteroPancreatic System (GEPNET-KUM), University-Hospital, Ludwig-Maximilians-University of Munich, Bavaria, Germany
⨯
Gerald Spöttl,

Affiliation Department of Internal Medicine II, Campus Grosshadern, Interdisciplinary Center of Neuroendocrine Tumours of the GastroEnteroPancreatic System (GEPNET-KUM), University-Hospital, Ludwig-Maximilians-University of Munich, Bavaria, Germany
⨯
Julian Maurer,

Affiliation Department of Internal Medicine II, Campus Grosshadern, Interdisciplinary Center of Neuroendocrine Tumours of the GastroEnteroPancreatic System (GEPNET-KUM), University-Hospital, Ludwig-Maximilians-University of Munich, Bavaria, Germany
⨯
Christoph Auernhammer

* E-mail: christoph.auernhammer@med.uni-muenchen.de

Affiliation Department of Internal Medicine II, Campus Grosshadern, Interdisciplinary Center of Neuroendocrine Tumours of the GastroEnteroPancreatic System (GEPNET-KUM), University-Hospital, Ludwig-Maximilians-University of Munich, Bavaria, Germany
⨯

The MTH1 inhibitor TH588 demonstrates anti-tumoral effects alone and in combination with everolimus, 5-FU and gamma-irradiation in neuroendocrine tumor cells

Elke Tatjana Aristizabal Prada,
Michael Orth,
Svenja Nölting,
Gerald Spöttl,
Julian Maurer,
Christoph Auernhammer

Published: May 25, 2017
https://doi.org/10.1371/journal.pone.0178375

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