Dissecting structures and functions of SecA-only protein-conducting channels: ATPase, pore structure, ion channel activity, protein translocation, and interaction with SecYEG/SecDF•YajC

Ying-hsin Hsieh; Ying-ju Huang; Hao Zhang; Qian Liu; Yang Lu; Hsiuchin Yang; John Houghton; Chun Jiang; Sen-Fang Sui; Phang C. Tai

doi:10.1371/journal.pone.0178307

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Peer-reviewed

Research Article

Dissecting structures and functions of SecA-only protein-conducting channels: ATPase, pore structure, ion channel activity, protein translocation, and interaction with SecYEG/SecDF•YajC

Ying-hsin Hsieh ,

Contributed equally to this work with: Ying-hsin Hsieh, Ying-ju Huang

Affiliation Department of Biology, Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA, United States of America
⨯
Ying-ju Huang ,

Contributed equally to this work with: Ying-hsin Hsieh, Ying-ju Huang

Affiliation Department of Biology, Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA, United States of America
⨯
Hao Zhang,

Affiliation Department of Biology, Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA, United States of America
⨯
Qian Liu,

Affiliation Department of Biology, Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA, United States of America
⨯
Yang Lu,

Affiliation Department of Biology, Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA, United States of America
⨯
Hsiuchin Yang †,

† Deceased.

Affiliation Department of Biology, Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA, United States of America
⨯
John Houghton,

Affiliation Department of Biology, Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA, United States of America
⨯
Chun Jiang,

Affiliation Department of Biology, Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA, United States of America
⨯
Sen-Fang Sui,

Affiliation State Key Laboratory of Membrane Biology, Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing China
⨯
Phang C. Tai

* E-mail: biopct@gsu.edu

Affiliation Department of Biology, Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA, United States of America

http://orcid.org/0000-0003-4217-9531

⨯

Dissecting structures and functions of SecA-only protein-conducting channels: ATPase, pore structure, ion channel activity, protein translocation, and interaction with SecYEG/SecDF•YajC

Ying-hsin Hsieh,
Ying-ju Huang,
Hao Zhang,
Qian Liu,
Yang Lu,
Hsiuchin Yang,
John Houghton,
Chun Jiang,
Sen-Fang Sui,
Phang C. Tai

Published: June 2, 2017
https://doi.org/10.1371/journal.pone.0178307

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