The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy

Tsutomu Iwata; Tairin Uchino; Ayako Koyama; Yoshikazu Johmura; Kenichi Koyama; Takuya Saito; Seiji Ishiguro; Takashi Arikawa; Shunichiro Komatsu; Masahiko Miyachi; Tsuyoshi Sano; Makoto Nakanishi; Midori Shimada

doi:10.1371/journal.pone.0178221

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Open Access

Peer-reviewed

Research Article

The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy

Tsutomu Iwata,

Affiliations Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Aichi, Japan, Department of Gastroenterological Surgery, Aichi Medical University School of Medicine, Nagakute, Japan
⨯
Tairin Uchino,

Affiliations Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Aichi, Japan, Department of Gastroenterological Surgery, Aichi Medical University School of Medicine, Nagakute, Japan
⨯
Ayako Koyama,

Affiliation Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Aichi, Japan
⨯
Yoshikazu Johmura,

Affiliations Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Aichi, Japan, Division of Cancer Cell Biology, Department of Cancer Biology, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan
⨯
Kenichi Koyama,

Affiliation Department of Gastroenterological Surgery, Aichi Medical University School of Medicine, Nagakute, Japan
⨯
Takuya Saito,

Affiliation Department of Gastroenterological Surgery, Aichi Medical University School of Medicine, Nagakute, Japan
⨯
Seiji Ishiguro,

Affiliation Department of Gastroenterological Surgery, Aichi Medical University School of Medicine, Nagakute, Japan
⨯
Takashi Arikawa,

Affiliation Department of Gastroenterological Surgery, Aichi Medical University School of Medicine, Nagakute, Japan
⨯
Shunichiro Komatsu,

Affiliation Department of Gastroenterological Surgery, Aichi Medical University School of Medicine, Nagakute, Japan
⨯
Masahiko Miyachi,

Affiliation Department of Gastroenterological Surgery, Aichi Medical University School of Medicine, Nagakute, Japan
⨯
Tsuyoshi Sano,

Affiliation Department of Gastroenterological Surgery, Aichi Medical University School of Medicine, Nagakute, Japan
⨯
Makoto Nakanishi,

Affiliations Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Aichi, Japan, Division of Cancer Cell Biology, Department of Cancer Biology, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan
⨯
Midori Shimada

* E-mail: shimada@yamaguchi-u.ac.jp

Current address: Department of Biochemistry, Joint Faculty of Veterinary Science, Yamaguchi University, Yoshida, Yamaguchi, Japan

Affiliation Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Aichi, Japan

http://orcid.org/0000-0002-2718-8600

⨯

The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy

Tsutomu Iwata,
Tairin Uchino,
Ayako Koyama,
Yoshikazu Johmura,
Kenichi Koyama,
Takuya Saito,
Seiji Ishiguro,
Takashi Arikawa,
Shunichiro Komatsu,
Masahiko Miyachi

Published: May 30, 2017
https://doi.org/10.1371/journal.pone.0178221

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