Gastrointestinal adverse events during methylphenidate treatment of children and adolescents with attention deficit hyperactivity disorder: A systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials

• Mathilde Holmskov ,

  * E-mail: mathildeholmskov@gmail.com

  Affiliations Psychiatric Research Unit, Region Zealand Psychiatry, Slagelse, Denmark, Child and Adolescent Psychiatric Department, Region Zealand, Denmark

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• Ole Jakob Storebø,

  Affiliations Psychiatric Research Unit, Region Zealand Psychiatry, Slagelse, Denmark, Child and Adolescent Psychiatric Department, Region Zealand, Denmark, Psychological Institute, Faculty of Health Science, University of Southern Denmark, Odense, Denmark

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• Carlos R. Moreira-Maia,

  Affiliation Federal University of Rio Grande do Sul, Porto Alegre, Brazil

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• Erica Ramstad,

  Affiliations Psychiatric Research Unit, Region Zealand Psychiatry, Slagelse, Denmark, Child and Adolescent Psychiatric Department, Region Zealand, Denmark

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• Frederik Løgstrup Magnusson,

  Affiliations Psychiatric Research Unit, Region Zealand Psychiatry, Slagelse, Denmark, Child and Adolescent Psychiatric Department, Region Zealand, Denmark

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• Helle B. Krogh,

  Affiliations Psychiatric Research Unit, Region Zealand Psychiatry, Slagelse, Denmark, Child and Adolescent Psychiatric Department, Region Zealand, Denmark

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• Camilla Groth,

  Affiliation Pediatric Department E, Herlev University Hospital, Herlev, Denmark

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• Donna Gillies,

  Affiliation Western Sydney Local Health District; Mental Health, Parramatta, Australia

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• Morris Zwi,

  Affiliation Islington CAMHS, Whittington Health, London, United Kingdom

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• Maria Skoog,

  Affiliation Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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• Christian Gluud,

  Affiliations Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, The Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

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• Erik Simonsen

  Affiliations Psychiatric Research Unit, Region Zealand Psychiatry, Slagelse, Denmark, Institute of Clinical Medicine, Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark

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