Plasmid-free CRISPR/Cas9 genome editing in Plasmodium falciparum confirms mutations conferring resistance to the dihydroisoquinolone clinical candidate SJ733

• Emily D. Crawford,

  Affiliations Chan Zuckerberg Biohub, San Francisco, California, United States of America, Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

  http://orcid.org/0000-0003-4182-2337

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• Jenai Quan,

  Affiliations Chan Zuckerberg Biohub, San Francisco, California, United States of America, Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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• Jeremy A. Horst,

  Affiliation Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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• Daniel Ebert,

  Current address: Touro College of Osteopathic Medicine, Middletown, New York, United States of America

  Affiliations Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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• Wesley Wu,

  Affiliation Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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• Joseph L. DeRisi

  * E-mail: joe@czbiohub.org

  Affiliations Chan Zuckerberg Biohub, San Francisco, California, United States of America, Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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