SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume

• Siying Zou,

  Affiliation Department of Cell Biology, Yale School of Medicine, New Haven, Connecticut, United States of America

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• Alexandra M. Teixeira,

  Affiliation Department of Pathology, Yale School of Medicine, New Haven, Connecticut, United States of America

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• Myrto Kostadima,

  Affiliation Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom

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• William J. Astle,

  Current address: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

  Affiliation Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom

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• Aparna Radhakrishnan,

  Affiliation Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom

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• Lukas Mikolaj Simon,

  Affiliation Department of Structural and Computational Biology, Baylor College of Medicine, Houston, TX, United States of America

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• Lucy Truman,

  Affiliation Department of ENT, Addenbrooke’s Hospital, Cambridge Biomedical Campus, Cambridge, United Kingdom

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• Jennifer S. Fang,

  Affiliation Yale Cardiovascular Research Center, Department of Cardiology, Yale University School of Medicine, New Haven, CT, United States of America

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• John Hwa,

  Affiliation Yale Cardiovascular Research Center, Department of Cardiology, Yale University School of Medicine, New Haven, CT, United States of America

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• Ping-xia Zhang,

  Affiliations Department of Laboratory Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America, Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut, United States of America

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• Pim van der Harst,

  Affiliations University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, The Netherlands, University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands

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• Paul F. Bray,

  Current address: MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

  Affiliation Department of Medicine and the Program in Molecular Medicine, University of Utah, Salt Lake City, Utah, United States of America

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• Willem H. Ouwehand,

  Affiliation Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom

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• Mattia Frontini,

  Affiliation Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom

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• Diane S. Krause

  * E-mail: diane.krause@yale.edu

  Affiliations Department of Cell Biology, Yale School of Medicine, New Haven, Connecticut, United States of America, Department of Pathology, Yale School of Medicine, New Haven, Connecticut, United States of America, Department of Laboratory Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America, Yale Stem Cell Center, Yale School of Medicine, New Haven, Connecticut, United States of America

  http://orcid.org/0000-0001-9420-6947

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