T0001, a variant of TNFR2-Fc fusion protein, exhibits improved Fc effector functions through increased binding to membrane-bound TNFα

Yijun Shen; Gang Li; Chunying Gu; Ben Chen; Aihua Chen; Hua Li; Bei Gao; Chencai Liang; Jingsong Wu; Tong Yang; Li Jin; Yong Su

doi:10.1371/journal.pone.0177891

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Open Access

Peer-reviewed

Research Article

T0001, a variant of TNFR2-Fc fusion protein, exhibits improved Fc effector functions through increased binding to membrane-bound TNFα

Yijun Shen ,

Contributed equally to this work with: Yijun Shen, Gang Li

Affiliations Ministry of Education Key Laboratory of Contemporary Anthropology, Fudan University, Shanghai, China, R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China
⨯
Gang Li ,

Contributed equally to this work with: Yijun Shen, Gang Li

Affiliation R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China
⨯
Chunying Gu,

Affiliation R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China
⨯
Ben Chen,

Affiliation R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China
⨯
Aihua Chen,

Affiliation R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China
⨯
Hua Li,

Affiliation R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China
⨯
Bei Gao,

Affiliation R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China
⨯
Chencai Liang,

Affiliation R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China
⨯
Jingsong Wu,

Affiliation R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China
⨯
Tong Yang,

Affiliation R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China
⨯
Li Jin ,

* E-mail: lijin.fudan@gmail.com (LJ); ysu@fd-zj.com (YS)

Affiliation Ministry of Education Key Laboratory of Contemporary Anthropology, Fudan University, Shanghai, China
⨯
Yong Su

* E-mail: lijin.fudan@gmail.com (LJ); ysu@fd-zj.com (YS)

Affiliation R&D Department of Genetic Engineering, Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd., Shanghai, China

http://orcid.org/0000-0002-6206-1664

⨯

T0001, a variant of TNFR2-Fc fusion protein, exhibits improved Fc effector functions through increased binding to membrane-bound TNFα

Yijun Shen,
Gang Li,
Chunying Gu,
Ben Chen,
Aihua Chen,
Hua Li,
Bei Gao,
Chencai Liang,
Jingsong Wu,
Tong Yang

Published: May 19, 2017
https://doi.org/10.1371/journal.pone.0177891

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