HSP90 inhibitors potentiate PGF2α-induced IL-6 synthesis via p38 MAP kinase in osteoblasts

Kazuhiko Fujita; Haruhiko Tokuda; Gen Kuroyanagi; Naohiro Yamamoto; Shingo Kainuma; Tetsu Kawabata; Go Sakai; Rie Matsushima-Nishiwaki; Osamu Kozawa; Takanobu Otsuka

doi:10.1371/journal.pone.0177878

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Open Access

Peer-reviewed

Research Article

HSP90 inhibitors potentiate PGF_2α-induced IL-6 synthesis via p38 MAP kinase in osteoblasts

Kazuhiko Fujita,

Affiliations Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Haruhiko Tokuda,

Affiliations Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan, Department of Clinical Laboratory/Biobank of Medical Genome Center, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan
⨯
Gen Kuroyanagi,

Affiliations Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Naohiro Yamamoto,

Affiliations Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Shingo Kainuma,

Affiliations Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Tetsu Kawabata,

Affiliations Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Go Sakai,

Affiliations Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Rie Matsushima-Nishiwaki,

Affiliation Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Osamu Kozawa ,

* E-mail: okozawa@gifu-u.ac.jp

Affiliation Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan

http://orcid.org/0000-0002-4834-6073

⨯
Takanobu Otsuka

Affiliation Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
⨯

HSP90 inhibitors potentiate PGF_2α-induced IL-6 synthesis via p38 MAP kinase in osteoblasts

Kazuhiko Fujita,
Haruhiko Tokuda,
Gen Kuroyanagi,
Naohiro Yamamoto,
Shingo Kainuma,
Tetsu Kawabata,
Go Sakai,
Rie Matsushima-Nishiwaki,
Osamu Kozawa,
Takanobu Otsuka

Published: May 19, 2017
https://doi.org/10.1371/journal.pone.0177878

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