The percentage of Epidermal Growth Factor Receptor (EGFR)-mutated neoplastic cells correlates to response to tyrosine kinase inhibitors in lung adenocarcinoma

Dario de Biase; Giovenzio Genestreti; Michela Visani; Giorgia Acquaviva; Monica Di Battista; Giovanna Cavallo; Alexandro Paccapelo; Alessandra Cancellieri; Rocco Trisolini; Roberta Degli Esposti; Stefania Bartolini; Annalisa Pession; Giovanni Tallini; Alba A. Brandes

doi:10.1371/journal.pone.0177822

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Peer-reviewed

Research Article

The percentage of Epidermal Growth Factor Receptor (EGFR)-mutated neoplastic cells correlates to response to tyrosine kinase inhibitors in lung adenocarcinoma

Dario de Biase ,

Contributed equally to this work with: Dario de Biase, Giovenzio Genestreti

* E-mail: dario.debiase@unibo.it (DdB); g.genestreti@ausl.bologna.it (GG)

Affiliation Department of Pharmacy and Biotechnology (Dipartimento di Farmacia e Biotecnologie) - Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna, Bologna, Italy

http://orcid.org/0000-0002-0609-8817

⨯
Giovenzio Genestreti ,

Contributed equally to this work with: Dario de Biase, Giovenzio Genestreti

* E-mail: dario.debiase@unibo.it (DdB); g.genestreti@ausl.bologna.it (GG)

Affiliation Department of Oncology, AUSL Bologna – IRCCS Institute of Neurological Sciences, Bologna, Italy
⨯
Michela Visani,

Affiliation Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale) - Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna School of Medicine, Bologna, Italy
⨯
Giorgia Acquaviva,

Affiliation Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale) - Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna School of Medicine, Bologna, Italy
⨯
Monica Di Battista,

Affiliation Department of Oncology, AUSL Bologna – IRCCS Institute of Neurological Sciences, Bologna, Italy
⨯
Giovanna Cavallo,

Affiliation Department of Oncology, AUSL Bologna – IRCCS Institute of Neurological Sciences, Bologna, Italy
⨯
Alexandro Paccapelo,

Affiliation Department of Oncology, AUSL Bologna – IRCCS Institute of Neurological Sciences, Bologna, Italy
⨯
Alessandra Cancellieri,

Affiliation Anatomic Pathology Unit, AUSL Bologna, Maggiore Hospital, Bologna, Italy
⨯
Rocco Trisolini,

Affiliation Interventional Pulmology, Sant'Orsola, Malpighi Hospital, Bologna, Italy
⨯
Roberta Degli Esposti,

Affiliation Department of Oncology, AUSL Bologna – IRCCS Institute of Neurological Sciences, Bologna, Italy
⨯
Stefania Bartolini,

Affiliation Department of Oncology, AUSL Bologna – IRCCS Institute of Neurological Sciences, Bologna, Italy
⨯
Annalisa Pession,

Affiliation Department of Pharmacy and Biotechnology (Dipartimento di Farmacia e Biotecnologie) - Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna, Bologna, Italy
⨯
Giovanni Tallini ,

¶‡ These authors are joint senior authors on this work.

Affiliation Department of Medicine (Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale) - Molecular Diagnostic Unit, Azienda USL di Bologna, University of Bologna School of Medicine, Bologna, Italy
⨯
Alba A. Brandes

¶‡ These authors are joint senior authors on this work.

Affiliation Department of Oncology, AUSL Bologna – IRCCS Institute of Neurological Sciences, Bologna, Italy
⨯

The percentage of Epidermal Growth Factor Receptor (EGFR)-mutated neoplastic cells correlates to response to tyrosine kinase inhibitors in lung adenocarcinoma

Dario de Biase,
Giovenzio Genestreti,
Michela Visani,
Giorgia Acquaviva,
Monica Di Battista,
Giovanna Cavallo,
Alexandro Paccapelo,
Alessandra Cancellieri,
Rocco Trisolini,
Roberta Degli Esposti

Published: May 16, 2017
https://doi.org/10.1371/journal.pone.0177822

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