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Open Access

Peer-reviewed

Research Article

Autophagy inhibitor facilitates gefitinib sensitivity in vitro and in vivo by activating mitochondrial apoptosis in triple negative breast cancer

Zhaoyun Liu ,

Contributed equally to this work with: Zhaoyun Liu, Kewen He

Affiliations School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China, Department of Oncology, Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Kewen He ,

Contributed equally to this work with: Zhaoyun Liu, Kewen He

Affiliations School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China, Department of Oncology, Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Qinghua Ma,

Affiliation Department of Oncology, Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong, China
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Qian Yu,

Affiliation University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
⨯
Chenyu Liu,

Affiliation Department of Biology, Winship Cancer Institute, Emory University, Atlanta, Georgia, United States of America
⨯
Isabella Ndege,

Affiliations School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China, Department of Oncology, Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Xinzhao Wang,

Affiliation Department of Oncology, Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong, China
⨯
Zhiyong Yu

* E-mail: drzhiyongyu@aliyun.com

Affiliation Department of Oncology, Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong, China

http://orcid.org/0000-0002-2569-9458

⨯

Autophagy inhibitor facilitates gefitinib sensitivity in vitro and in vivo by activating mitochondrial apoptosis in triple negative breast cancer

Zhaoyun Liu,
Kewen He,
Qinghua Ma,
Qian Yu,
Chenyu Liu,
Isabella Ndege,
Xinzhao Wang,
Zhiyong Yu

x

Published: May 22, 2017
https://doi.org/10.1371/journal.pone.0177694

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Autophagic cell death
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Apoptosis
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Cancer treatment
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Mitochondria
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DNA damage
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Breast cancer
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Drug therapy
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Cancers and neoplasms
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