Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacity

Hiroshi Sakai; Sumiaki Fukuda; Miki Nakamura; Akiyoshi Uezumi; Yu-taro Noguchi; Takahiko Sato; Mitsuhiro Morita; Harumoto Yamada; Kunihiro Tsuchida; Shahragim Tajbakhsh; So-ichiro Fukada

doi:10.1371/journal.pone.0177516

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Open Access

Peer-reviewed

Research Article

Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacity

Hiroshi Sakai ,

Contributed equally to this work with: Hiroshi Sakai, Sumiaki Fukuda

Affiliation Stem Cells & Development, Department of Developmental & Stem Cell Biology, CNRS UMR 3738, Institut Pasteur, Paris, France
⨯
Sumiaki Fukuda ,

Contributed equally to this work with: Hiroshi Sakai, Sumiaki Fukuda

Affiliation Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
⨯
Miki Nakamura,

Affiliation Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
⨯
Akiyoshi Uezumi,

Affiliation Division for Therapies Against Intractable Diseases, Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan
⨯
Yu-taro Noguchi,

Affiliation Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
⨯
Takahiko Sato,

Affiliation Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
⨯
Mitsuhiro Morita,

Affiliation Department of Orthopaedic Surgery, Fujita Health University, Aichi, Japan
⨯
Harumoto Yamada,

Affiliation Department of Orthopaedic Surgery, Fujita Health University, Aichi, Japan
⨯
Kunihiro Tsuchida,

Affiliation Division for Therapies Against Intractable Diseases, Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan
⨯
Shahragim Tajbakhsh ,

* E-mail: shahragim.tajbakhsh@pasteur.fr (ST); fukada@phs.osaka-u.ac.jp (SF)

Affiliation Stem Cells & Development, Department of Developmental & Stem Cell Biology, CNRS UMR 3738, Institut Pasteur, Paris, France
⨯
So-ichiro Fukada

* E-mail: shahragim.tajbakhsh@pasteur.fr (ST); fukada@phs.osaka-u.ac.jp (SF)

Affiliation Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan

http://orcid.org/0000-0003-4051-5108

⨯

Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacity

Hiroshi Sakai,
Sumiaki Fukuda,
Miki Nakamura,
Akiyoshi Uezumi,
Yu-taro Noguchi,
Takahiko Sato,
Mitsuhiro Morita,
Harumoto Yamada,
Kunihiro Tsuchida,
Shahragim Tajbakhsh

Published: May 12, 2017
https://doi.org/10.1371/journal.pone.0177516

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Myoblasts
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Muscle cells
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Stem cell therapy
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Muscle regeneration
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Notch signaling
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Muscle differentiation
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