Contribution of thrombin-reactive brain pericytes to blood-brain barrier dysfunction in an in vivo mouse model of obesity-associated diabetes and an in vitro rat model

Takashi Machida; Fuyuko Takata; Junichi Matsumoto; Tomoyuki Miyamura; Ryosuke Hirata; Ikuya Kimura; Yasufumi Kataoka; Shinya Dohgu; Atsushi Yamauchi

doi:10.1371/journal.pone.0177447

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Open Access

Peer-reviewed

Research Article

Contribution of thrombin-reactive brain pericytes to blood-brain barrier dysfunction in an in vivo mouse model of obesity-associated diabetes and an in vitro rat model

Takashi Machida,

Affiliation Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
⨯
Fuyuko Takata,

Affiliations Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan, BBB Laboratory, PharmaCo-Cell Co., Ltd., Nagasaki, Japan
⨯
Junichi Matsumoto,

Affiliation Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
⨯
Tomoyuki Miyamura,

Affiliation Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
⨯
Ryosuke Hirata,

Affiliation Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
⨯
Ikuya Kimura,

Affiliation Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
⨯
Yasufumi Kataoka,

Affiliations Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan, BBB Laboratory, PharmaCo-Cell Co., Ltd., Nagasaki, Japan
⨯
Shinya Dohgu,

Affiliation Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
⨯
Atsushi Yamauchi

* E-mail: atyama@fukuoka-u.ac.jp

Affiliation Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
⨯

Contribution of thrombin-reactive brain pericytes to blood-brain barrier dysfunction in an in vivo mouse model of obesity-associated diabetes and an in vitro rat model

Takashi Machida,
Fuyuko Takata,
Junichi Matsumoto,
Tomoyuki Miyamura,
Ryosuke Hirata,
Ikuya Kimura,
Yasufumi Kataoka,
Shinya Dohgu,
Atsushi Yamauchi

Published: May 10, 2017
https://doi.org/10.1371/journal.pone.0177447

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