Deletion of Shp2 in bronchial epithelial cells impairs IL-25 production in vitro, but has minor influence on asthmatic inflammation in vivo

Zhangwei Qiu; Jiesen Zhou; Fang Liu; Xuejun Qin; Yuanrong Dai; Yuehai Ke; Zhihua Chen; Wen Li; Songmin Ying; Huahao Shen

doi:10.1371/journal.pone.0177334

Loading metrics

Open Access

Peer-reviewed

Research Article

Deletion of Shp2 in bronchial epithelial cells impairs IL-25 production in vitro, but has minor influence on asthmatic inflammation in vivo

Zhangwei Qiu,

Affiliations Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, Department of Pulmonary Medicine, Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯
Jiesen Zhou,

Affiliation Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Fang Liu,

Affiliation Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Xuejun Qin,

Affiliation Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Yuanrong Dai,

Affiliation Department of Pulmonary Medicine, Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯
Yuehai Ke,

Affiliation Department of Pathology and Pathophysiology, Program in Molecular Cell Biology and Institute of Respiratory Disease, Zhejiang University School of Medicine, Hangzhou, China
⨯
Zhihua Chen,

Affiliation Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Wen Li,

Affiliation Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Songmin Ying,

Affiliation Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Huahao Shen

* E-mail: huahaoshen@163.com

Affiliations Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, State Key Lab for Respiratory Diseases, Guangzhou, China

http://orcid.org/0000-0002-0350-5480

⨯

Deletion of Shp2 in bronchial epithelial cells impairs IL-25 production in vitro, but has minor influence on asthmatic inflammation in vivo

Zhangwei Qiu,
Jiesen Zhou,
Fang Liu,
Xuejun Qin,
Yuanrong Dai,
Yuehai Ke,
Zhihua Chen,
Wen Li,
Songmin Ying,
Huahao Shen

Published: May 8, 2017
https://doi.org/10.1371/journal.pone.0177334

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Epithelial cells
Is the Subject Area "Epithelial cells" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Allergies
Is the Subject Area "Allergies" applicable to this article?

Thanks for your feedback.
Genetically modified animals
Is the Subject Area "Genetically modified animals" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Asthma
Is the Subject Area "Asthma" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.