Haemophilus parasuis cytolethal distending toxin induces cell cycle arrest and p53-dependent apoptosis

Gang Li; Hui Niu; Yanhe Zhang; Yanling Li; Fang Xie; Paul R. Langford; Siguo Liu; Chunlai Wang

doi:10.1371/journal.pone.0177199

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Open Access

Peer-reviewed

Research Article

Haemophilus parasuis cytolethal distending toxin induces cell cycle arrest and p53-dependent apoptosis

Gang Li ,

Contributed equally to this work with: Gang Li, Hui Niu

Affiliation State Key Laboratory of Veterinary Biotechnology, Division of Bacterial Diseases, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China
⨯
Hui Niu ,

Contributed equally to this work with: Gang Li, Hui Niu

Affiliation State Key Laboratory of Veterinary Biotechnology, Division of Bacterial Diseases, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China
⨯
Yanhe Zhang,

Affiliation State Key Laboratory of Veterinary Biotechnology, Division of Bacterial Diseases, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China
⨯
Yanling Li,

Affiliation State Key Laboratory of Veterinary Biotechnology, Division of Bacterial Diseases, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China
⨯
Fang Xie,

Affiliation State Key Laboratory of Veterinary Biotechnology, Division of Bacterial Diseases, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China
⨯
Paul R. Langford,

Affiliation Section of Paediatrics, Department of Medicine, Imperial College London, St. Mary’s Campus, London, United Kingdom
⨯
Siguo Liu,

Affiliation State Key Laboratory of Veterinary Biotechnology, Division of Bacterial Diseases, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China
⨯
Chunlai Wang

* E-mail: chunlai.w@hvri.ac.cn

Affiliation State Key Laboratory of Veterinary Biotechnology, Division of Bacterial Diseases, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

http://orcid.org/0000-0001-9586-7114

⨯

Haemophilus parasuis cytolethal distending toxin induces cell cycle arrest and p53-dependent apoptosis

Gang Li,
Hui Niu,
Yanhe Zhang,
Yanling Li,
Fang Xie,
Paul R. Langford,
Siguo Liu,
Chunlai Wang

Published: May 18, 2017
https://doi.org/10.1371/journal.pone.0177199

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Cell cycle and cell division
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Deoxyribonucleases
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DNA damage
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