Common variation in the sodium/glucose cotransporter 2 gene SLC5A2 does neither affect fasting nor glucose-suppressed plasma glucagon concentrations

Anna-Maria Ordelheide; Anja Böhm; Daniela Kempe-Teufel; Robert Wagner; Fausto Machicao; Martin Heni; Norbert Stefan; Andreas Fritsche; Hans-Ulrich Häring; Harald Staiger

doi:10.1371/journal.pone.0177148

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Research Article

Common variation in the sodium/glucose cotransporter 2 gene SLC5A2 does neither affect fasting nor glucose-suppressed plasma glucagon concentrations

Anna-Maria Ordelheide,

Affiliations Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany, German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany
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Anja Böhm,

Affiliations Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany, German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany
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Daniela Kempe-Teufel,

Affiliations Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany, German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany
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Robert Wagner,

Affiliations Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany, German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany
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Fausto Machicao,

Affiliations Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany, German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany, Institute of Experimental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany
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Martin Heni,

Affiliations Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany, German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany
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Norbert Stefan,

Affiliations Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany, German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany
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Andreas Fritsche,

Affiliations Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany, German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany, Division of Nutritional and Preventive Medicine, Department of Internal Medicine, University Hospital Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany
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Hans-Ulrich Häring,

Affiliations Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany, German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany, Interfaculty Center for Pharmacogenomics and Pharma Research at the Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen, Germany
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Harald Staiger

* E-mail: harald.staiger@med.uni-tuebingen.de

Affiliations Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany, German Center for Diabetes Research (DZD), Otfried-Müller-Straße 10, Tübingen, Germany, Institute of Experimental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany, Interfaculty Center for Pharmacogenomics and Pharma Research at the Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen, Germany, Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls University Tübingen, Auf der Morgenstelle 8, Tübingen, Germany

http://orcid.org/0000-0002-9507-5333

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Common variation in the sodium/glucose cotransporter 2 gene SLC5A2 does neither affect fasting nor glucose-suppressed plasma glucagon concentrations

Anna-Maria Ordelheide,
Anja Böhm,
Daniela Kempe-Teufel,
Robert Wagner,
Fausto Machicao,
Martin Heni,
Norbert Stefan,
Andreas Fritsche,
Hans-Ulrich Häring,
Harald Staiger

Published: May 4, 2017
https://doi.org/10.1371/journal.pone.0177148

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