A natural product-like JAK2/STAT3 inhibitor induces apoptosis of malignant melanoma cells

Ke-Jia Wu; Jie-Min Huang; Hai-Jing Zhong; Zhen-Zhen Dong; Kasipandi Vellaisamy; Jin-Jian Lu; Xiu-Ping Chen; Pauline Chiu; Daniel W. J. Kwong; Quan-Bin Han; Dik-Lung Ma; Chung-Hang Leung

doi:10.1371/journal.pone.0177123

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Open Access

Peer-reviewed

Research Article

A natural product-like JAK2/STAT3 inhibitor induces apoptosis of malignant melanoma cells

Ke-Jia Wu ,

Contributed equally to this work with: Ke-Jia Wu, Jie-Min Huang

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
⨯
Jie-Min Huang ,

Contributed equally to this work with: Ke-Jia Wu, Jie-Min Huang

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
⨯
Hai-Jing Zhong,

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
⨯
Zhen-Zhen Dong,

Affiliation Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
⨯
Kasipandi Vellaisamy,

Affiliation Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
⨯
Jin-Jian Lu,

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
⨯
Xiu-Ping Chen,

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
⨯
Pauline Chiu,

Affiliations Department of Chemistry, The University of Hong Kong, Hong Kong, China, The State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong, China
⨯
Daniel W. J. Kwong,

Affiliation Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
⨯
Quan-Bin Han,

Affiliation School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
⨯
Dik-Lung Ma ,

* E-mail: duncanleung@umac.mo (CHL); edmondma@hkbu.edu.hk (DLM)

Affiliation Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
⨯
Chung-Hang Leung

* E-mail: duncanleung@umac.mo (CHL); edmondma@hkbu.edu.hk (DLM)

Affiliation State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China

http://orcid.org/0000-0003-2988-3786

⨯

A natural product-like JAK2/STAT3 inhibitor induces apoptosis of malignant melanoma cells

Ke-Jia Wu,
Jie-Min Huang,
Hai-Jing Zhong,
Zhen-Zhen Dong,
Kasipandi Vellaisamy,
Jin-Jian Lu,
Xiu-Ping Chen,
Pauline Chiu,
Daniel W. J. Kwong,
Quan-Bin Han

Published: June 1, 2017
https://doi.org/10.1371/journal.pone.0177123

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