Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis

Romy M. W. Kremers; Marie-Claire Kleinegris; Marisa Ninivaggi; Bas de Laat; Hugo ten Cate; Ger H. Koek; Rob J. Wagenvoord; H. Coenraad Hemker

doi:10.1371/journal.pone.0177020

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Open Access

Peer-reviewed

Research Article

Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis

Romy M. W. Kremers ,

* E-mail: r.kremers@thrombin.com

Affiliations Synapse Research Institute, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands, Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands

http://orcid.org/0000-0001-6526-0338

⨯
Marie-Claire Kleinegris,

Affiliation Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands
⨯
Marisa Ninivaggi,

Affiliation Synapse Research Institute, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands
⨯
Bas de Laat,

Affiliations Synapse Research Institute, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands, Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands
⨯
Hugo ten Cate,

Affiliation Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands
⨯
Ger H. Koek,

Affiliation Department of Internal Medicine, Division of Gastroenterology and Hepatology, Maastricht University Medical Center, Maastricht, the Netherlands
⨯
Rob J. Wagenvoord,

Affiliation Synapse Research Institute, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands
⨯
H. Coenraad Hemker

Affiliation Synapse Research Institute, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands
⨯

Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis

Romy M. W. Kremers,
Marie-Claire Kleinegris,
Marisa Ninivaggi,
Bas de Laat,
Hugo ten Cate,
Ger H. Koek,
Rob J. Wagenvoord,
H. Coenraad Hemker

Published: May 4, 2017
https://doi.org/10.1371/journal.pone.0177020

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