T1R3 homomeric sweet taste receptor regulates adipogenesis through Gαs-mediated microtubules disassembly and Rho activation in 3T3-L1 cells

Yosuke Masubuchi; Yuko Nakagawa; Johan Medina; Masahiro Nagasawa; Itaru Kojima; Mark M. Rasenick; Takeshi Inagaki; Hiroshi Shibata

doi:10.1371/journal.pone.0176841

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Peer-reviewed

Research Article

T1R3 homomeric sweet taste receptor regulates adipogenesis through Gαs-mediated microtubules disassembly and Rho activation in 3T3-L1 cells

Yosuke Masubuchi,

Affiliation Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, Japan
⨯
Yuko Nakagawa,

Affiliation Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, Japan
⨯
Johan Medina,

Affiliation Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, Japan
⨯
Masahiro Nagasawa,

Affiliation Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, Japan
⨯
Itaru Kojima,

Affiliation Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, Japan
⨯
Mark M. Rasenick,

Affiliation Departments of Physiology & Biophysics and Psychiatry, University of Illinois, Chicago, Illinois, United States of America; and the Jesse Brown VA Medical Center, Chicago, Illinois, United States of America
⨯
Takeshi Inagaki,

Affiliation Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, Japan
⨯
Hiroshi Shibata

* E-mail: hshibata@gunma-u.ac.jp

Affiliation Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, Japan

http://orcid.org/0000-0002-4215-0141

⨯

T1R3 homomeric sweet taste receptor regulates adipogenesis through Gαs-mediated microtubules disassembly and Rho activation in 3T3-L1 cells

Yosuke Masubuchi,
Yuko Nakagawa,
Johan Medina,
Masahiro Nagasawa,
Itaru Kojima,
Mark M. Rasenick,
Takeshi Inagaki,
Hiroshi Shibata

Published: May 4, 2017
https://doi.org/10.1371/journal.pone.0176841

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Microtubules
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Taste
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Guanosine triphosphatase
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Immunoblotting
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Transfection
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Receptor physiology
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Adipocytes
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