The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction

• Motoi Kobayashi,

  Affiliation Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan

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• Fumitake Usui-Kawanishi,

  Affiliation Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan

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• Tadayoshi Karasawa,

  Affiliation Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan

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• Hiroaki Kimura,

  Affiliation Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan

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• Sachiko Watanabe,

  Affiliation Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan

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• Nathan Mise,

  Affiliation Department of Environmental and Preventive Medicine, Jichi Medical University, Tochigi, Japan

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• Fujio Kayama,

  Affiliation Department of Environmental and Preventive Medicine, Jichi Medical University, Tochigi, Japan

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• Tadashi Kasahara,

  Affiliation Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan

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• Naoyuki Hasebe,

  Affiliation Department of Medicine, Division of Cardiovascular, Respiratory and Neurology, Asahikawa Medical University, Hokkaido, Japan

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• Masafumi Takahashi

  * E-mail: masafumi2@jichi.ac.jp

  Affiliation Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan

  http://orcid.org/0000-0003-2716-7532

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