The anti-microbial peptide TP359 attenuates inflammation in human lung cells infected with Pseudomonas aeruginosa via TLR5 and MAPK pathways

Ejovwoke F. Dosunmu; Robert O. Emeh; Saurabh Dixit; Mona K. Bakeer; Mamie T. Coats; Donald R. Owen; Shreekumar R. Pillai; Shree R. Singh; Vida A. Dennis

doi:10.1371/journal.pone.0176640

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Open Access

Peer-reviewed

Research Article

The anti-microbial peptide TP359 attenuates inflammation in human lung cells infected with Pseudomonas aeruginosa via TLR5 and MAPK pathways

Ejovwoke F. Dosunmu,

Current address: United States Department of Agriculture, United States Salinity Laboratory, Riverside, California, United States of America

Affiliation Center for NanoBiotechnology Research, Alabama State University, Montgomery, Alabama, United States of America

http://orcid.org/0000-0003-1380-4211

⨯
Robert O. Emeh,

Affiliation Center for NanoBiotechnology Research, Alabama State University, Montgomery, Alabama, United States of America
⨯
Saurabh Dixit,

Current address: National Institute of Health, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States America

Affiliation Center for NanoBiotechnology Research, Alabama State University, Montgomery, Alabama, United States of America
⨯
Mona K. Bakeer,

Affiliation Lousiana State University Health Sciences Center, School of Allied Health Professions, New Orleans, Louisiana, United States of America
⨯
Mamie T. Coats,

Affiliation Center for NanoBiotechnology Research, Alabama State University, Montgomery, Alabama, United States of America
⨯
Donald R. Owen,

Affiliation Therapeutic Peptides Inc., Baton Rouge, Louisiana, United States of America
⨯
Shreekumar R. Pillai,

Affiliation Center for NanoBiotechnology Research, Alabama State University, Montgomery, Alabama, United States of America
⨯
Shree R. Singh,

Affiliation Center for NanoBiotechnology Research, Alabama State University, Montgomery, Alabama, United States of America
⨯
Vida A. Dennis

* E-mail: vdennis@alasu.edu

Affiliation Center for NanoBiotechnology Research, Alabama State University, Montgomery, Alabama, United States of America
⨯

The anti-microbial peptide TP359 attenuates inflammation in human lung cells infected with Pseudomonas aeruginosa via TLR5 and MAPK pathways

Ejovwoke F. Dosunmu,
Robert O. Emeh,
Saurabh Dixit,
Mona K. Bakeer,
Mamie T. Coats,
Donald R. Owen,
Shreekumar R. Pillai,
Shree R. Singh,
Vida A. Dennis

Published: May 3, 2017
https://doi.org/10.1371/journal.pone.0176640

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Pseudomonas aeruginosa
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Cytokines
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Inflammation
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MAPK signaling cascades
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Toll-like receptors
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Flagellin
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