Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin

Pawel Zmora; Paulina Molau-Blazejewska; Stephanie Bertram; Kerstin Walendy-Gnirß; Inga Nehlmeier; Anika Hartleib; Anna-Sophie Moldenhauer; Sebastian Konzok; Susann Dehmel; Katherina Sewald; Constantin Brinkmann; Christoph Curths; Sascha Knauf; Jens Gruber; Kerstin Mätz-Rensing; Franziska Dahlmann; Armin Braun; Stefan Pöhlmann

doi:10.1371/journal.pone.0176597

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Peer-reviewed

Research Article

Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin

Pawel Zmora ,

Contributed equally to this work with: Pawel Zmora, Paulina Molau-Blazejewska

Current address: Department of Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstraße 1, Magdeburg, Germany

Affiliation Infection Biology Unit, German Primate Center, Leibniz-Institute Kellnerweg 4, Göttingen, Germany
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Paulina Molau-Blazejewska ,

Contributed equally to this work with: Pawel Zmora, Paulina Molau-Blazejewska

Affiliation Infection Biology Unit, German Primate Center, Leibniz-Institute Kellnerweg 4, Göttingen, Germany
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Stephanie Bertram,

Current address: Viral Zoonosis and Adaptation, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Martinistrasse 52, Hamburg, Germany

Affiliation Infection Biology Unit, German Primate Center, Leibniz-Institute Kellnerweg 4, Göttingen, Germany
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Kerstin Walendy-Gnirß,

Current address: Viral Zoonosis and Adaptation, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Martinistrasse 52, Hamburg, Germany

Affiliation Infection Biology Unit, German Primate Center, Leibniz-Institute Kellnerweg 4, Göttingen, Germany
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Inga Nehlmeier,

Affiliation Infection Biology Unit, German Primate Center, Leibniz-Institute Kellnerweg 4, Göttingen, Germany
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Anika Hartleib,

Affiliation Infection Biology Unit, German Primate Center, Leibniz-Institute Kellnerweg 4, Göttingen, Germany
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Anna-Sophie Moldenhauer,

Affiliation Infection Biology Unit, German Primate Center, Leibniz-Institute Kellnerweg 4, Göttingen, Germany
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Sebastian Konzok,

Affiliation Division Preclinical Pharmacology and In Vitro Toxicology, Fraunhofer Institute for Toxicology and Experimental Medicine; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Nikolai-Fuchs-Strasse 1, Hannover, Germany
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Susann Dehmel,

Affiliation Division Preclinical Pharmacology and In Vitro Toxicology, Fraunhofer Institute for Toxicology and Experimental Medicine; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Nikolai-Fuchs-Strasse 1, Hannover, Germany
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Katherina Sewald,

Affiliation Division Preclinical Pharmacology and In Vitro Toxicology, Fraunhofer Institute for Toxicology and Experimental Medicine; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Nikolai-Fuchs-Strasse 1, Hannover, Germany
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Constantin Brinkmann,

Affiliation Infection Biology Unit, German Primate Center, Leibniz-Institute Kellnerweg 4, Göttingen, Germany
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Christoph Curths,

Affiliations Division Preclinical Pharmacology and In Vitro Toxicology, Fraunhofer Institute for Toxicology and Experimental Medicine; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Nikolai-Fuchs-Strasse 1, Hannover, Germany, Pathology Unit, German Primate Center, Leibniz-Institute, Kellnerweg 4, Göttingen, Germany
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Sascha Knauf,

Affiliations Pathology Unit, German Primate Center, Leibniz-Institute, Kellnerweg 4, Göttingen, Germany, Workgroup Neglected Tropical Diseases, German Primate Center, Leibniz-Institute, Kellnerweg 4, Göttingen, Germany
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Jens Gruber,

Affiliation Primate Genetics Laboratory, Junior Research Group "Medical RNA Biology," German Primate Center, Leibniz-Institute, Göttingen, Germany
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Kerstin Mätz-Rensing,

Affiliation Pathology Unit, German Primate Center, Leibniz-Institute, Kellnerweg 4, Göttingen, Germany
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Franziska Dahlmann,

Affiliations Division Preclinical Pharmacology and In Vitro Toxicology, Fraunhofer Institute for Toxicology and Experimental Medicine; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Nikolai-Fuchs-Strasse 1, Hannover, Germany, Pathology Unit, German Primate Center, Leibniz-Institute, Kellnerweg 4, Göttingen, Germany
⨯
Armin Braun,

Affiliation Division Preclinical Pharmacology and In Vitro Toxicology, Fraunhofer Institute for Toxicology and Experimental Medicine; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, Nikolai-Fuchs-Strasse 1, Hannover, Germany
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[ ... ],
Stefan Pöhlmann

* E-mail: spoehlmann@dpz.eu

Affiliation Infection Biology Unit, German Primate Center, Leibniz-Institute Kellnerweg 4, Göttingen, Germany

http://orcid.org/0000-0001-6086-9136

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Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin

Pawel Zmora,
Paulina Molau-Blazejewska,
Stephanie Bertram,
Kerstin Walendy-Gnirß,
Inga Nehlmeier,
Anika Hartleib,
Anna-Sophie Moldenhauer,
Sebastian Konzok,
Susann Dehmel,
Katherina Sewald

Published: May 11, 2017
https://doi.org/10.1371/journal.pone.0176597

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