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Open Access

Peer-reviewed

Research Article

A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5

Madhushika Ratnayake,

Current address: Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

Affiliation Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Maria Tselepi ,

* E-mail: maria.tselepi@ncl.ac.uk

Current address: Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

Affiliation Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Robert Bloxham,

Current address: Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

Affiliation Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Frank Plöger,

Affiliation BioPharm GmbH, Heidelberg, Germany
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Louise N. Reynard,

Current address: Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

Affiliation Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
John Loughlin

Current address: Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

Affiliation Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

http://orcid.org/0000-0003-2018-3361

⨯

A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5

Madhushika Ratnayake,
Maria Tselepi,
Robert Bloxham,
Frank Plöger,
Louise N. Reynard,
John Loughlin

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Published: May 8, 2017
https://doi.org/10.1371/journal.pone.0176523

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Gene expression
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Cartilage
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Mesenchymal stem cells
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Chondrocytes
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Patients
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Osteoarthritis
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Cell differentiation
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Extracellular matrix
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