Prevalence and extent of heteroresistance by next generation sequencing of multidrug-resistant tuberculosis

Darwin J. Operario; Alexander F. Koeppel; Stephen D. Turner; Yongde Bao; Suporn Pholwat; Sayera Banu; Suporn Foongladda; Stellah Mpagama; Jean Gratz; Oleg Ogarkov; Svetlana Zhadova; Scott K. Heysell; Eric R. Houpt

doi:10.1371/journal.pone.0176522

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Open Access

Peer-reviewed

Research Article

Prevalence and extent of heteroresistance by next generation sequencing of multidrug-resistant tuberculosis

Darwin J. Operario,

Affiliation Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, United States of America
⨯
Alexander F. Koeppel,

Affiliation Department of Public Health Sciences, University of Virginia, Charlottesville, VA, United States of America
⨯
Stephen D. Turner,

Affiliation Department of Public Health Sciences, University of Virginia, Charlottesville, VA, United States of America
⨯
Yongde Bao,

Affiliation Department of Microbiology, University of Virginia, Charlottesville, VA, United States of America
⨯
Suporn Pholwat,

Affiliation Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, United States of America
⨯
Sayera Banu,

Affiliation International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
⨯
Suporn Foongladda,

Affiliation Siriraj Hospital, Mahidol University, Bangkok, Thailand
⨯
Stellah Mpagama,

Affiliation Kibong’oto Infectious Diseases Hospital, Kilimanjaro, Tanzania
⨯
Jean Gratz,

Affiliation Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, United States of America
⨯
Oleg Ogarkov,

Affiliation Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Siberia, Russian Federation
⨯
Svetlana Zhadova,

Affiliation Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Siberia, Russian Federation
⨯
Scott K. Heysell,

Affiliation Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, United States of America
⨯
Eric R. Houpt

* E-mail: erh6k@virginia.edu

Affiliation Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, United States of America

http://orcid.org/0000-0003-1085-1354

⨯

Prevalence and extent of heteroresistance by next generation sequencing of multidrug-resistant tuberculosis

Darwin J. Operario,
Alexander F. Koeppel,
Stephen D. Turner,
Yongde Bao,
Suporn Pholwat,
Sayera Banu,
Suporn Foongladda,
Stellah Mpagama,
Jean Gratz,
Oleg Ogarkov

Published: May 18, 2017
https://doi.org/10.1371/journal.pone.0176522

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Next-generation sequencing
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Genetic loci
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Tuberculosis
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Polymerase chain reaction
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Genomics
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Mycobacterium tuberculosis
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Dideoxy DNA sequencing
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