Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell

Sijia Chen; Jialong Tao; Fengyun Zhong; Yang Jiao; Jiaying Xu; Qiang Shen; Haichao Wang; Saijun Fan; Yusong Zhang

doi:10.1371/journal.pone.0176501

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Open Access

Peer-reviewed

Research Article

Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell

Sijia Chen ,

Contributed equally to this work with: Sijia Chen, Jialong Tao, Fengyun Zhong

Affiliation Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China
⨯
Jialong Tao ,

Contributed equally to this work with: Sijia Chen, Jialong Tao, Fengyun Zhong

Affiliation Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China
⨯
Fengyun Zhong ,

Contributed equally to this work with: Sijia Chen, Jialong Tao, Fengyun Zhong

Affiliation Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China
⨯
Yang Jiao,

Affiliation School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu, P.R. China
⨯
Jiaying Xu,

Affiliation School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu, P.R. China
⨯
Qiang Shen,

Affiliation Department of Clinical Cancer Prevention, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Haichao Wang,

Affiliation The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York, United States of America
⨯
Saijun Fan ,

* E-mail: zhangyusong19@163.com (YZ); fansaijun36@163.com (SF)

Affiliation School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu, P.R. China
⨯
Yusong Zhang

* E-mail: zhangyusong19@163.com (YZ); fansaijun36@163.com (SF)

Affiliation Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China

http://orcid.org/0000-0003-0474-5870

⨯

Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell

Sijia Chen,
Jialong Tao,
Fengyun Zhong,
Yang Jiao,
Jiaying Xu,
Qiang Shen,
Haichao Wang,
Saijun Fan,
Yusong Zhang

Published: May 3, 2017
https://doi.org/10.1371/journal.pone.0176501

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Breast cancer
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Apoptosis
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Cancer treatment
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Phosphorylation
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MTT assay
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