Inhibitory effects of fenretinide metabolites N-[4-methoxyphenyl]retinamide (MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (3-keto-HPR) on fenretinide molecular targets β-carotene oxygenase 1, stearoyl-CoA desaturase 1 and dihydroceramide Δ4-desaturase 1

• Eugenia Poliakov ,

  * E-mail: poliakove@nei.nih.gov (EP); redmondd@helix.nih.gov (TMR)

  Affiliation Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• William Samuel,

  Affiliation Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Todd Duncan,

  Affiliation Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Danielle B. Gutierrez,

  Affiliation Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Nathan L. Mata,

  Affiliation Acucela Inc., Seattle, Washington, United States of America

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• T. Michael Redmond

  * E-mail: poliakove@nei.nih.gov (EP); redmondd@helix.nih.gov (TMR)

  Affiliation Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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