The novel carboxylesterase 1 variant c.662A>G may decrease the bioactivation of oseltamivir in humans

Jaeseong Oh; SeungHwan Lee; Howard Lee; Joo-Youn Cho; Seo Hyun Yoon; In-Jin Jang; Kyung-Sang Yu; Kyoung Soo Lim

doi:10.1371/journal.pone.0176320

Loading metrics

Open Access

Peer-reviewed

Research Article

The novel carboxylesterase 1 variant c.662A>G may decrease the bioactivation of oseltamivir in humans

Jaeseong Oh,

Affiliation Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea

http://orcid.org/0000-0001-6275-8587

⨯
SeungHwan Lee,

Affiliation Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea
⨯
Howard Lee,

Affiliations Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea, Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea
⨯
Joo-Youn Cho,

Affiliation Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea
⨯
Seo Hyun Yoon,

Affiliation Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea
⨯
In-Jin Jang,

Affiliation Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea
⨯
Kyung-Sang Yu,

Affiliation Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea
⨯
Kyoung Soo Lim

* E-mail: dr.kyoungsoo.lim@gmail.com

Affiliation Department of Clinical Pharmacology and Therapeutics, CHA University School of Medicine and CHA Bundang Medical Center, Seongnam, Republic of Korea
⨯

The novel carboxylesterase 1 variant c.662A>G may decrease the bioactivation of oseltamivir in humans

Jaeseong Oh,
SeungHwan Lee,
Howard Lee,
Joo-Youn Cho,
Seo Hyun Yoon,
In-Jin Jang,
Kyung-Sang Yu,
Kyoung Soo Lim

Published: April 24, 2017
https://doi.org/10.1371/journal.pone.0176320

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Single nucleotide polymorphisms
Is the Subject Area "Single nucleotide polymorphisms" applicable to this article?

Thanks for your feedback.
Drug metabolism
Is the Subject Area "Drug metabolism" applicable to this article?

Thanks for your feedback.
Enzyme metabolism
Is the Subject Area "Enzyme metabolism" applicable to this article?

Thanks for your feedback.
Enzymes
Is the Subject Area "Enzymes" applicable to this article?

Thanks for your feedback.
Heterozygosity
Is the Subject Area "Heterozygosity" applicable to this article?

Thanks for your feedback.
Urine
Is the Subject Area "Urine" applicable to this article?

Thanks for your feedback.
Pharmacokinetics
Is the Subject Area "Pharmacokinetics" applicable to this article?

Thanks for your feedback.
Excretion
Is the Subject Area "Excretion" applicable to this article?

Thanks for your feedback.