The burden of trisomy 21 disrupts the proteostasis network in Down syndrome

Stefanos Aivazidis; Christina M. Coughlan; Abhishek K. Rauniyar; Hua Jiang; L. Alexander Liggett; Kenneth N. Maclean; James R. Roede

doi:10.1371/journal.pone.0176307

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Open Access

Peer-reviewed

Research Article

The burden of trisomy 21 disrupts the proteostasis network in Down syndrome

Stefanos Aivazidis ,

Contributed equally to this work with: Stefanos Aivazidis, Christina M. Coughlan

¶‡ These authors are co-first authors on this work.

Affiliation Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, United States of America
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Christina M. Coughlan ,

Contributed equally to this work with: Stefanos Aivazidis, Christina M. Coughlan

¶‡ These authors are co-first authors on this work.

Affiliations Department of Neurology, University of Colorado School of Medicine, Aurora, CO, United States of America, The Linda Crnic Institute for Down Syndrome, University of Colorado, Aurora, CO, United States of America
⨯
Abhishek K. Rauniyar,

Affiliation Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, United States of America
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Hua Jiang,

Affiliations The Linda Crnic Institute for Down Syndrome, University of Colorado, Aurora, CO, United States of America, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, United States of America
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L. Alexander Liggett,

Affiliations The Linda Crnic Institute for Down Syndrome, University of Colorado, Aurora, CO, United States of America, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, United States of America
⨯
Kenneth N. Maclean,

Affiliations The Linda Crnic Institute for Down Syndrome, University of Colorado, Aurora, CO, United States of America, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, United States of America
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James R. Roede

* E-mail: james.roede@ucdenver.edu

Affiliation Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, United States of America

http://orcid.org/0000-0002-8425-6366

⨯

The burden of trisomy 21 disrupts the proteostasis network in Down syndrome

Stefanos Aivazidis,
Christina M. Coughlan,
Abhishek K. Rauniyar,
Hua Jiang,
L. Alexander Liggett,
Kenneth N. Maclean,
James R. Roede

Published: April 21, 2017
https://doi.org/10.1371/journal.pone.0176307

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Fibroblasts
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Down syndrome
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Heat shock response
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Cell disruption
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