Next generation sequencing to dissect the genetic architecture of KNG1 and F11 loci using factor XI levels as an intermediate phenotype of thrombosis

Laura Martin-Fernandez; Giovana Gavidia-Bovadilla; Irene Corrales; Helena Brunel; Lorena Ramírez; Sonia López; Juan Carlos Souto; Francisco Vidal; José Manuel Soria

doi:10.1371/journal.pone.0176301

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Open Access

Peer-reviewed

Research Article

Next generation sequencing to dissect the genetic architecture of KNG1 and F11 loci using factor XI levels as an intermediate phenotype of thrombosis

Laura Martin-Fernandez,

Affiliation Unit of Genomics of Complex Diseases, Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain
⨯
Giovana Gavidia-Bovadilla,

Affiliations Unit of Genomics of Complex Diseases, Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain, Department of ESAII, Center for Biomedical Engineering Research (CREB), Universitat Politècnica de Catalunya, Barcelona, Spain
⨯
Irene Corrales,

Affiliations Congenital Coagulopathies, Blood and Tissue Bank, Barcelona, Spain, Molecular Diagnosis and Therapy, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain
⨯
Helena Brunel,

Affiliation Unit of Genomics of Complex Diseases, Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain
⨯
Lorena Ramírez,

Affiliations Congenital Coagulopathies, Blood and Tissue Bank, Barcelona, Spain, Molecular Diagnosis and Therapy, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain
⨯
Sonia López,

Affiliation Unit of Genomics of Complex Diseases, Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain
⨯
Juan Carlos Souto,

Affiliation Unit of Hemostasis and Thrombosis, Department of Hematology, IIB-Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
⨯
Francisco Vidal,

Affiliations Congenital Coagulopathies, Blood and Tissue Bank, Barcelona, Spain, Molecular Diagnosis and Therapy, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain, CIBER de Enfermedades Cardiovasculares, Barcelona, Spain
⨯
José Manuel Soria

* E-mail: JSoria@santpau.cat

Affiliation Unit of Genomics of Complex Diseases, Biomedical Research Institute Sant Pau (IIB-Sant Pau), Barcelona, Spain
⨯

Next generation sequencing to dissect the genetic architecture of KNG1 and F11 loci using factor XI levels as an intermediate phenotype of thrombosis

Laura Martin-Fernandez,
Giovana Gavidia-Bovadilla,
Irene Corrales,
Helena Brunel,
Lorena Ramírez,
Sonia López,
Juan Carlos Souto,
Francisco Vidal,
José Manuel Soria

Published: April 26, 2017
https://doi.org/10.1371/journal.pone.0176301

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