Alpha-1 antitrypsin supplementation improves alveolar macrophages efferocytosis and phagocytosis following cigarette smoke exposure

Karina A. Serban; Daniela N. Petrusca; Andrew Mikosz; Christophe Poirier; Angelia D. Lockett; Lauren Saint; Matthew J. Justice; Homer L. Twigg III; Michael A. Campos; Irina Petrache

doi:10.1371/journal.pone.0176073

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Peer-reviewed

Research Article

Alpha-1 antitrypsin supplementation improves alveolar macrophages efferocytosis and phagocytosis following cigarette smoke exposure

Karina A. Serban ,

* E-mail: serbank@njhealth.org

Affiliations Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, Colorado, United States of America, Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Daniela N. Petrusca,

Affiliations Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Department of Medicine, Divisions of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
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Andrew Mikosz,

Affiliation Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, Colorado, United States of America
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Christophe Poirier †,

† Deceased.

Affiliation Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
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Angelia D. Lockett,

Affiliations Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Department of Cellular and Integrative Physiology at Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Lauren Saint,

Affiliation Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
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Matthew J. Justice,

Affiliations Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, Colorado, United States of America, Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Homer L. Twigg III,

Affiliation Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
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Michael A. Campos,

Affiliation Division of Pulmonary and Critical Care Medicine, University of Miami, Miami, Florida, United States of America
⨯
Irina Petrache

Affiliations Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, Colorado, United States of America, Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯

Alpha-1 antitrypsin supplementation improves alveolar macrophages efferocytosis and phagocytosis following cigarette smoke exposure

Karina A. Serban,
Daniela N. Petrusca,
Andrew Mikosz,
Christophe Poirier,
Angelia D. Lockett,
Lauren Saint,
Matthew J. Justice,
Homer L. Twigg III,
Michael A. Campos,
Irina Petrache

Published: April 27, 2017
https://doi.org/10.1371/journal.pone.0176073

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Cell membranes
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Chronic obstructive pulmonary disease
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Macrophages
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