Human β-defensin-2 production upon viral and bacterial co-infection is attenuated in COPD

Jason W. Arnason; James C. Murphy; Cora Kooi; Shahina Wiehler; Suzanne L. Traves; Christopher Shelfoon; Barbara Maciejewski; Curtis J. Dumonceaux; W. Shawn Lewenza; David Proud; Richard Leigh

doi:10.1371/journal.pone.0175963

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Open Access

Peer-reviewed

Research Article

Human β-defensin-2 production upon viral and bacterial co-infection is attenuated in COPD

Jason W. Arnason,

Affiliations Department of Medicine, Snyder Institute for Chronic Diseases, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada, Department of Physiology & Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada
⨯
James C. Murphy,

Affiliation Department of Physiology & Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada
⨯
Cora Kooi,

Affiliations Department of Medicine, Snyder Institute for Chronic Diseases, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada, Department of Physiology & Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada
⨯
Shahina Wiehler,

Affiliation Department of Physiology & Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada
⨯
Suzanne L. Traves,

Affiliation Department of Physiology & Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada
⨯
Christopher Shelfoon,

Affiliation Department of Physiology & Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada
⨯
Barbara Maciejewski,

Affiliation Department of Physiology & Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada
⨯
Curtis J. Dumonceaux,

Affiliations Department of Medicine, Snyder Institute for Chronic Diseases, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada, Department of Physiology & Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada
⨯
W. Shawn Lewenza,

Affiliation Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada
⨯
David Proud,

Affiliation Department of Physiology & Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada
⨯
Richard Leigh

* E-mail: rleigh@ucalgary.ca

Affiliations Department of Medicine, Snyder Institute for Chronic Diseases, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada, Department of Physiology & Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada
⨯

Human β-defensin-2 production upon viral and bacterial co-infection is attenuated in COPD

Jason W. Arnason,
James C. Murphy,
Cora Kooi,
Shahina Wiehler,
Suzanne L. Traves,
Christopher Shelfoon,
Barbara Maciejewski,
Curtis J. Dumonceaux,
W. Shawn Lewenza,
David Proud

Published: May 10, 2017
https://doi.org/10.1371/journal.pone.0175963

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Co-infections
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Chronic obstructive pulmonary disease
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Small interfering RNA
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Pseudomonas aeruginosa
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Rhinovirus infection
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