Accurate detection of low prevalence AKT1 E17K mutation in tissue or plasma from advanced cancer patients

Open Access

Peer-reviewed

Research Article

Elza C. de Bruin ,

* E-mail: elza.de-bruin@astrazeneca.com

Affiliation Personalised Healthcare and Biomarkers, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom
⨯
Jessica L. Whiteley,

Affiliation Personalised Healthcare and Biomarkers, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom
⨯
Claire Corcoran,

Affiliation Personalised Healthcare and Biomarkers, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom
⨯
Pauline M. Kirk,

Affiliation Personalised Healthcare and Biomarkers, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom
⨯
Jayne C. Fox,

Affiliation Personalised Healthcare and Biomarkers, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom
⨯
Javier Armisen,

Affiliation Horizon Discovery Ltd, Cambridge, United Kingdom
⨯
Justin P. O. Lindemann,

Affiliation Early Clinical Development, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom
⨯
Gaia Schiavon,

Affiliation Translational Science, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom
⨯
Helen J. Ambrose,

Affiliation Early Clinical Development, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom
⨯
Alexander Kohlmann

Affiliation Personalised Healthcare and Biomarkers, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom
⨯

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Mutation detection
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Breast cancer
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Gynecologic cancers
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Matrix-assisted laser desorption ionization time-of-flight mass spectrometry
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Polymerase chain reaction
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Signal amplification
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Blood plasma
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Ovarian cancer
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