Reconstruction of 3D structures of MET antibodies from electron microscopy 2D class averages

Qi Chen; Michal Vieth; David E. Timm; Christine Humblet; Dina Schneidman-Duhovny; Ilan E. Chemmama; Andrej Sali; Wei Zeng; Jirong Lu; Ling Liu

doi:10.1371/journal.pone.0175758

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Open Access

Peer-reviewed

Research Article

Reconstruction of 3D structures of MET antibodies from electron microscopy 2D class averages

Qi Chen ,

* E-mail: chen_qi_qc@lilly.com (QC); vieth_michal@lilly.com (MV)

Affiliation Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America

http://orcid.org/0000-0003-1256-0366

⨯
Michal Vieth ,

* E-mail: chen_qi_qc@lilly.com (QC); vieth_michal@lilly.com (MV)

Affiliation Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America
⨯
David E. Timm,

Affiliation Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America
⨯
Christine Humblet,

Affiliation Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America

http://orcid.org/0000-0003-1775-4426

⨯
Dina Schneidman-Duhovny,

Affiliation Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute of Quantitative Biosciences, University of California, San Francisco, San Francisco, California, United States of America
⨯
Ilan E. Chemmama,

Affiliation Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute of Quantitative Biosciences, University of California, San Francisco, San Francisco, California, United States of America
⨯
Andrej Sali,

Affiliation Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute of Quantitative Biosciences, University of California, San Francisco, San Francisco, California, United States of America
⨯
Wei Zeng,

Affiliation Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America
⨯
Jirong Lu,

Affiliation Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America
⨯
Ling Liu

Affiliation Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, United States of America
⨯

Reconstruction of 3D structures of MET antibodies from electron microscopy 2D class averages

Qi Chen,
Michal Vieth,
David E. Timm,
Christine Humblet,
Dina Schneidman-Duhovny,
Ilan E. Chemmama,
Andrej Sali,
Wei Zeng,
Jirong Lu,
Ling Liu

Published: April 13, 2017
https://doi.org/10.1371/journal.pone.0175758

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