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Soaking suggests “alternative facts”: Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition
- Frederik Rainer Ehrmann,
- Johann Stojko,
- Alexander Metz,
- François Debaene,
- Luzi Jakob Barandun,
- Andreas Heine,
- François Diederich,
- Sarah Cianférani,
- Klaus Reuter,
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Gerhard Klebe
* E-mail: klebe@mailer.uni-marburg.de
Affiliation Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marburg, Germany
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http://orcid.org/0000-0002-4913-390X
Soaking suggests “alternative facts”: Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition
- Frederik Rainer Ehrmann,
- Johann Stojko,
- Alexander Metz,
- François Debaene,
- Luzi Jakob Barandun,
- Andreas Heine,
- François Diederich,
- Sarah Cianférani,
- Klaus Reuter,
- Gerhard Klebe
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- Published: April 18, 2017
- https://doi.org/10.1371/journal.pone.0175723