A randomised controlled trial of losartan as an anti-fibrotic agent in non-alcoholic steatohepatitis

Stuart McPherson; Nina Wilkinson; Dina Tiniakos; Jennifer Wilkinson; Alastair D. Burt; Elaine McColl; Deborah D. Stocken; Nick Steen; Jane Barnes; Nicola Goudie; Stephen Stewart; Yvonne Bury; Derek Mann; Quentin M. Anstee; Christopher P. Day

doi:10.1371/journal.pone.0175717

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Open Access

Peer-reviewed

Research Article

A randomised controlled trial of losartan as an anti-fibrotic agent in non-alcoholic steatohepatitis

Stuart McPherson ,

* E-mail: stuart.mcpherson@nuth.nhs.uk

Affiliations Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom, Liver Unit, Newcastle Upon Tyne Hospitals NHS Trust, Freeman Hospital, Newcastle upon Tyne, United Kingdom

http://orcid.org/0000-0002-5638-2453

⨯
Nina Wilkinson,

Affiliation Institute of Health and Society, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Dina Tiniakos,

Affiliations Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom, Department of Pathology, Newcastle Upon Tyne Hospitals NHS Trust, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom, Medical School, National & Kapodistrian University of Athens, Athens, Greece
⨯
Jennifer Wilkinson,

Affiliation Newcastle Clinical Trials Unit, Faculty of Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Alastair D. Burt,

Affiliation Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia
⨯
Elaine McColl,

Affiliations Institute of Health and Society, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, United Kingdom, Newcastle Clinical Trials Unit, Faculty of Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Deborah D. Stocken,

Affiliation Institute of Health and Society, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Nick Steen,

Affiliation Institute of Health and Society, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Jane Barnes,

Affiliation Newcastle Clinical Trials Unit, Faculty of Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Nicola Goudie,

Affiliation Newcastle Clinical Trials Unit, Faculty of Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Stephen Stewart,

Affiliation Department of Gastroenterology, Mater Misericordiae University Hospital, Dublin, Ireland
⨯
Yvonne Bury,

Affiliation Medical School, National & Kapodistrian University of Athens, Athens, Greece
⨯
Derek Mann,

Affiliation Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Quentin M. Anstee,

Affiliations Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom, Liver Unit, Newcastle Upon Tyne Hospitals NHS Trust, Freeman Hospital, Newcastle upon Tyne, United Kingdom
⨯
Christopher P. Day

Affiliations Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom, Liver Unit, Newcastle Upon Tyne Hospitals NHS Trust, Freeman Hospital, Newcastle upon Tyne, United Kingdom
⨯

A randomised controlled trial of losartan as an anti-fibrotic agent in non-alcoholic steatohepatitis

Stuart McPherson,
Nina Wilkinson,
Dina Tiniakos,
Jennifer Wilkinson,
Alastair D. Burt,
Elaine McColl,
Deborah D. Stocken,
Nick Steen,
Jane Barnes,
Nicola Goudie

Published: April 18, 2017
https://doi.org/10.1371/journal.pone.0175717

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Fibrosis
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Liver fibrosis
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Fatty liver
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Renin-angiotensin system
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Steatosis
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