Mini-G proteins: Novel tools for studying GPCRs in their active conformation

Rony Nehmé; Byron Carpenter; Ankita Singhal; Annette Strege; Patricia C. Edwards; Courtney F. White; Haijuan Du; Reinhard Grisshammer; Christopher G. Tate

doi:10.1371/journal.pone.0175642

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Peer-reviewed

Research Article

Mini-G proteins: Novel tools for studying GPCRs in their active conformation

Rony Nehmé,

Affiliation MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
⨯
Byron Carpenter,

Current address: Warwick Integrative Synthetic Biology Centre, School of Life Sciences, Gibbet Hill Campus, University of Warwick, Warwick, United Kingdom

Affiliation MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
⨯
Ankita Singhal,

Affiliation MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
⨯
Annette Strege,

Affiliation MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
⨯
Patricia C. Edwards,

Affiliation MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
⨯
Courtney F. White,

Affiliation Membrane Protein Structure Function Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Services, Rockville, United States of America
⨯
Haijuan Du,

Affiliation Membrane Protein Structure Function Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Services, Rockville, United States of America
⨯
Reinhard Grisshammer,

Affiliation Membrane Protein Structure Function Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Services, Rockville, United States of America
⨯
Christopher G. Tate

* E-mail: cgt@mrc-lmb.cam.ac.uk

Affiliation MRC Laboratory of Molecular Biology, Cambridge, United Kingdom

http://orcid.org/0000-0002-2008-9183

⨯

Mini-G proteins: Novel tools for studying GPCRs in their active conformation

Rony Nehmé,
Byron Carpenter,
Ankita Singhal,
Annette Strege,
Patricia C. Edwards,
Courtney F. White,
Haijuan Du,
Reinhard Grisshammer,
Christopher G. Tate

Published: April 20, 2017
https://doi.org/10.1371/journal.pone.0175642

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G protein coupled receptors
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Receptor binding assays
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