Identification of a plasma metabolomic signature of thrombotic myocardial infarction that is distinct from non-thrombotic myocardial infarction and stable coronary artery disease

Andrew P. DeFilippis; Patrick J. Trainor; Bradford G. Hill; Alok R. Amraotkar; Shesh N. Rai; Glenn A. Hirsch; Eric C. Rouchka; Aruni Bhatnagar

doi:10.1371/journal.pone.0175591

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Open Access

Peer-reviewed

Research Article

Identification of a plasma metabolomic signature of thrombotic myocardial infarction that is distinct from non-thrombotic myocardial infarction and stable coronary artery disease

Andrew P. DeFilippis ,

* E-mail: APDeFi01@louisville.edu

Affiliations Department of Medicine, Division of Cardiovascular Medicine, Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky, United States of America, Johns Hopkins University, Baltimore, Maryland, United States of America

http://orcid.org/0000-0002-5135-9748

⨯
Patrick J. Trainor,

Affiliation Department of Medicine, Division of Bioinformatics, University of Louisville, Louisville, Kentucky, United States of America
⨯
Bradford G. Hill,

Affiliation Department of Medicine, Division of Cardiovascular Medicine, Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky, United States of America
⨯
Alok R. Amraotkar,

Affiliation Department of Medicine, Division of Cardiovascular Medicine, Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky, United States of America
⨯
Shesh N. Rai,

Affiliation Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, Kentucky, United States of America
⨯
Glenn A. Hirsch,

Affiliation Department of Medicine, Division of Cardiovascular Medicine, Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky, United States of America
⨯
Eric C. Rouchka,

Affiliation Department of Computer Engineering and Computer Science, University of Louisville, Louisville, Kentucky, United States of America
⨯
Aruni Bhatnagar

Affiliation Department of Medicine, Division of Cardiovascular Medicine, Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky, United States of America
⨯

Identification of a plasma metabolomic signature of thrombotic myocardial infarction that is distinct from non-thrombotic myocardial infarction and stable coronary artery disease

Andrew P. DeFilippis,
Patrick J. Trainor,
Bradford G. Hill,
Alok R. Amraotkar,
Shesh N. Rai,
Glenn A. Hirsch,
Eric C. Rouchka,
Aruni Bhatnagar

Published: April 17, 2017
https://doi.org/10.1371/journal.pone.0175591

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Myocardial infarction
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Stable coronary artery disease
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Metabolites
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Lipid metabolism
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Troponin
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Catheterization
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Necrosis
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