Reactive oxygen species are required for driving efficient and sustained aerobic glycolysis during CD4+ T cell activation

Open Access

Peer-reviewed

Research Article

Reactive oxygen species are required for driving efficient and sustained aerobic glycolysis during CD4⁺ T cell activation

Dana M. Previte,

Affiliations Department of Surgery, Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America, Department of Immunology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Erin C. O’Connor,

Affiliation Department of Surgery, Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
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Elizabeth A. Novak,

Affiliation Department of Surgery, Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
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Christina P. Martins,

Affiliation Department of Surgery, Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
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Kevin P. Mollen,

Affiliation Department of Surgery, Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
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Jon D. Piganelli

* E-mail: jdp51@pitt.edu

Affiliations Department of Surgery, Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America, Department of Immunology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

http://orcid.org/0000-0003-2699-9011

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T cells
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Glycolysis
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Cell metabolism
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Diabetes mellitus
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Redox signaling
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Cell cycle and cell division
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Flow cytometry
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Oxidation-reduction reactions
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