Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1

Shuiling Jin; Hairui Su; Ngoc-Tung Tran; Jing Song; Sydney S. Lu; Ying Li; Suming Huang; Omar Abdel-Wahab; Yanyan Liu; Xinyang Zhao

doi:10.1371/journal.pone.0175523

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Open Access

Peer-reviewed

Research Article

Splicing factor SF3B1^K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1

Shuiling Jin,

Affiliations Department of Internal Medicine, Henan Cancer Hospital & Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China, Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Hairui Su,

Affiliation Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Ngoc-Tung Tran,

Affiliation Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Jing Song,

Affiliation Department of Internal Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⨯
Sydney S. Lu,

Affiliation Human Oncology & Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Ying Li,

Affiliation Macau Institute for Applied Research in Medicine and Health, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau. China
⨯
Suming Huang,

Affiliation Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
Omar Abdel-Wahab,

Affiliation Human Oncology & Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Yanyan Liu ,

* E-mail: yyliu@zzu.edu.cn (YYL); zhaox88@uab.edu (XZ)

Affiliation Department of Internal Medicine, Henan Cancer Hospital & Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China
⨯
Xinyang Zhao

* E-mail: yyliu@zzu.edu.cn (YYL); zhaox88@uab.edu (XZ)

Affiliation Department of Biochemistry and Molecular Genetics, The University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯

Splicing factor SF3B1^K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1

Shuiling Jin,
Hairui Su,
Ngoc-Tung Tran,
Jing Song,
Sydney S. Lu,
Ying Li,
Suming Huang,
Omar Abdel-Wahab,
Yanyan Liu,
Xinyang Zhao

Published: May 18, 2017
https://doi.org/10.1371/journal.pone.0175523

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Transcription factors
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Cell differentiation
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RNA splicing
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