Reduction in the copy number and expression level of the recurrent human papillomavirus integration gene fragile histidine triad (FHIT) predicts the transition of cervical lesions

Liming Wang; Hui Shen; Bei Feng; Da Zhu; Lan Yu; Xun Tian; Ci Ren; Chun Gao; Xiaomin Li; Ding Ma; Zheng Hu; Hui Wang

doi:10.1371/journal.pone.0175520

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Open Access

Peer-reviewed

Research Article

Reduction in the copy number and expression level of the recurrent human papillomavirus integration gene fragile histidine triad (FHIT) predicts the transition of cervical lesions

Liming Wang,

Affiliation Key Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

http://orcid.org/0000-0003-3354-2079

⨯
Hui Shen,

Affiliation Key Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Bei Feng,

Affiliation Key Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Da Zhu,

Affiliation Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Lan Yu,

Affiliation Key Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Xun Tian,

Affiliation Key Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Ci Ren,

Affiliation Key Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Chun Gao,

Affiliation Key Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Xiaomin Li,

Affiliation Key Laboratory of Cancer Invasion and Metastasis of the Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Ding Ma ,

* E-mail: dma@tjh.tjmu.edu.cn (DM); 18627803527@163.com (ZH); huit71@sohu.com (HW)

Affiliation Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Zheng Hu ,

* E-mail: dma@tjh.tjmu.edu.cn (DM); 18627803527@163.com (ZH); huit71@sohu.com (HW)

Affiliations Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China
⨯
Hui Wang

* E-mail: dma@tjh.tjmu.edu.cn (DM); 18627803527@163.com (ZH); huit71@sohu.com (HW)

Affiliation Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

http://orcid.org/0000-0001-6789-5185

⨯

Reduction in the copy number and expression level of the recurrent human papillomavirus integration gene fragile histidine triad (FHIT) predicts the transition of cervical lesions

Liming Wang,
Hui Shen,
Bei Feng,
Da Zhu,
Lan Yu,
Xun Tian,
Ci Ren,
Chun Gao,
Xiaomin Li,
Ding Ma

Published: April 17, 2017
https://doi.org/10.1371/journal.pone.0175520

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Human papillomavirus
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Human genomics
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Protein expression
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