The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro

Kawaljit Kaur; Xiaoqing Wu; James K. Fields; David K. Johnson; Lan Lan; Miranda Pratt; Amber D. Somoza; Clay C. C. Wang; John Karanicolas; Berl R. Oakley; Liang Xu; Roberto N. De Guzman

doi:10.1371/journal.pone.0175471

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Open Access

Peer-reviewed

Research Article

The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro

Kawaljit Kaur ,

Contributed equally to this work with: Kawaljit Kaur, Xiaoqing Wu

Affiliation Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States of America
⨯
Xiaoqing Wu ,

Contributed equally to this work with: Kawaljit Kaur, Xiaoqing Wu

Affiliation Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States of America
⨯
James K. Fields,

Affiliation Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States of America
⨯
David K. Johnson,

Affiliation Molecular Graphics and Modeling Laboratory and the Computational Chemical Biology Core, University of Kansas, Lawrence, Kansas, United States of America
⨯
Lan Lan,

Affiliation Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States of America
⨯
Miranda Pratt,

Affiliation Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States of America
⨯
Amber D. Somoza,

Affiliation Department of Chemistry, University of Southern California, Los Angeles, California, United States of America
⨯
Clay C. C. Wang,

Affiliations Department of Chemistry, University of Southern California, Los Angeles, California, United States of America, Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California United States of America
⨯
John Karanicolas,

Affiliations Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States of America, Center for Computational Biology, University of Kansas, Lawrence, Kansas, United States of America
⨯
Berl R. Oakley,

Affiliation Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States of America
⨯
Liang Xu,

Affiliation Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States of America
⨯
Roberto N. De Guzman

* E-mail: rdguzman@ku.edu

Affiliation Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States of America

http://orcid.org/0000-0003-1172-2917

⨯

The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro

Kawaljit Kaur,
Xiaoqing Wu,
James K. Fields,
David K. Johnson,
Lan Lan,
Miranda Pratt,
Amber D. Somoza,
Clay C. C. Wang,
John Karanicolas,
Berl R. Oakley

Published: April 17, 2017
https://doi.org/10.1371/journal.pone.0175471

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