Disruption of outer blood-retinal barrier by Toxoplasma gondii-infected monocytes is mediated by paracrinely activated FAK signaling

Hyun Beom Song; Hyoung-Oh Jun; Jin Hyoung Kim; Young-Ha Lee; Min-Ho Choi; Jeong Hun Kim

doi:10.1371/journal.pone.0175159

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Peer-reviewed

Research Article

Disruption of outer blood-retinal barrier by Toxoplasma gondii-infected monocytes is mediated by paracrinely activated FAK signaling

Hyun Beom Song,

Affiliations Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea, Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul, Republic of Korea
⨯
Hyoung-Oh Jun,

Affiliation Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
⨯
Jin Hyoung Kim,

Affiliation Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
⨯
Young-Ha Lee,

Affiliation Department of Infection Biology, Chungnam National University School of Medicine, Daejeon, Republic of Korea
⨯
Min-Ho Choi ,

* E-mail: steph25@snu.ac.kr (JHK); mhchoi@snu.ac.kr (MHC)

Affiliation Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul, Republic of Korea
⨯
Jeong Hun Kim

* E-mail: steph25@snu.ac.kr (JHK); mhchoi@snu.ac.kr (MHC)

Affiliations Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea, Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea, Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Republic of Korea
⨯

Disruption of outer blood-retinal barrier by Toxoplasma gondii-infected monocytes is mediated by paracrinely activated FAK signaling

Hyun Beom Song,
Hyoung-Oh Jun,
Jin Hyoung Kim,
Young-Ha Lee,
Min-Ho Choi,
Jeong Hun Kim

Published: April 13, 2017
https://doi.org/10.1371/journal.pone.0175159

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Monocytes
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Toxoplasma gondii
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Tachyzoites
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Tight junctions
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Cell disruption
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Signal inhibition
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Electrical resistance
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