Abnormal repression of SHP-1, SHP-2 and SOCS-1 transcription sustains the activation of the JAK/STAT3 pathway and the progression of the disease in multiple myeloma

Asma Beldi-Ferchiou; Nour Skouri; Cyrine Ben Ali; Ines Safra; Abderrahman Abdelkefi; Saloua Ladeb; Karima Mrad; Tarek Ben Othman; Mélika Ben Ahmed

doi:10.1371/journal.pone.0174835

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Open Access

Peer-reviewed

Research Article

Abnormal repression of SHP-1, SHP-2 and SOCS-1 transcription sustains the activation of the JAK/STAT3 pathway and the progression of the disease in multiple myeloma

Asma Beldi-Ferchiou,

Current address: Assistance Publique Hôpitaux de Paris (AP-HP), Groupe Hospitalier Mondor, Department of Biological Hematology and Immunology, Créteil, France

Affiliation Institut Pasteur de Tunis, Laboratory of Clinical Immunology, Tunis, Tunisia

http://orcid.org/0000-0002-7806-9687

⨯
Nour Skouri,

Affiliation Institut Pasteur de Tunis, Laboratory of Clinical Immunology, Tunis, Tunisia
⨯
Cyrine Ben Ali,

Affiliation Institut Pasteur de Tunis, Laboratory of Clinical Immunology, Tunis, Tunisia
⨯
Ines Safra,

Affiliations Institut Pasteur de Tunis, Laboratory of Molecular and Cellular Hematology, Tunis, Tunisia, Université de Tunis El Manar, Faculté de Médecine de Tunis, Tunis, Tunisie
⨯
Abderrahman Abdelkefi,

Affiliation Bone Marrow Transplantation Center, Tunis, Tunisia
⨯
Saloua Ladeb,

Affiliations Université de Tunis El Manar, Faculté de Médecine de Tunis, Tunis, Tunisie, Bone Marrow Transplantation Center, Tunis, Tunisia
⨯
Karima Mrad,

Affiliations Université de Tunis El Manar, Faculté de Médecine de Tunis, Tunis, Tunisie, Salah Azaiez Institute, Department of Pathology, Tunis, Tunisia
⨯
Tarek Ben Othman,

Affiliations Université de Tunis El Manar, Faculté de Médecine de Tunis, Tunis, Tunisie, Bone Marrow Transplantation Center, Tunis, Tunisia
⨯
Mélika Ben Ahmed

* E-mail: melika.benahmed@pasteur.rns.tn

Affiliations Institut Pasteur de Tunis, Laboratory of Clinical Immunology, Tunis, Tunisia, Université de Tunis El Manar, Faculté de Médecine de Tunis, Tunis, Tunisie
⨯

Abnormal repression of SHP-1, SHP-2 and SOCS-1 transcription sustains the activation of the JAK/STAT3 pathway and the progression of the disease in multiple myeloma

Asma Beldi-Ferchiou,
Nour Skouri,
Cyrine Ben Ali,
Ines Safra,
Abderrahman Abdelkefi,
Saloua Ladeb,
Karima Mrad,
Tarek Ben Othman,
Mélika Ben Ahmed

Published: April 3, 2017
https://doi.org/10.1371/journal.pone.0174835

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Gene expression
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Plasma cells
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Multiple myeloma
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Bone marrow cells
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Gene regulation
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Suppressor genes
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Cancer treatment
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