Codon-level co-occurrences of germline variants and somatic mutations in cancer are rare but often lead to incorrect variant annotation and underestimated impact prediction

• Amanda Koire ,

  * E-mail: koire@bcm.edu

  Affiliations Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, United States of America, Medical Scientist Training Program, Baylor College of Medicine, Houston, Texas, United States of America

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• Young Won Kim,

  Affiliation Program in Integrative Molecular and Biomedical Sciences, Baylor College of Medicine, Houston, Texas, United States of America

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• Jarey Wang,

  Affiliation Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, United States of America

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• Panagiotis Katsonis,

  Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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• Haijing Jin,

  Affiliation Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, United States of America

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• Olivier Lichtarge

  Affiliations Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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