Vitamin D receptor gene is epigenetically altered and transcriptionally up-regulated in multiple sclerosis

Teresa Ayuso; Patricia Aznar; Luis Soriano; Ander Olaskoaga; Miren Roldán; María Otano; Iratxe Ajuria; Gerardo Soriano; Francisco Lacruz; Maite Mendioroz

doi:10.1371/journal.pone.0174726

Loading metrics

Open Access

Peer-reviewed

Research Article

Vitamin D receptor gene is epigenetically altered and transcriptionally up-regulated in multiple sclerosis

Teresa Ayuso ,

Contributed equally to this work with: Teresa Ayuso, Patricia Aznar

Affiliation Multiple Sclerosis Unit, Department of Neurology, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain
⨯
Patricia Aznar ,

Contributed equally to this work with: Teresa Ayuso, Patricia Aznar

Affiliation Department of Neurology, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain
⨯
Luis Soriano,

Affiliation Neuroepigenetics Laboratory, Navarrabiomed- Navarra Institute for Health Research (IdiSNA), Pamplona, Navarra, Spain
⨯
Ander Olaskoaga,

Affiliation Department of Neurology, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain
⨯
Miren Roldán,

Affiliation Neuroepigenetics Laboratory, Navarrabiomed- Navarra Institute for Health Research (IdiSNA), Pamplona, Navarra, Spain
⨯
María Otano,

Affiliation Multiple Sclerosis Unit, Department of Neurology, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain
⨯
Iratxe Ajuria,

Affiliation Multiple Sclerosis Unit, Department of Neurology, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain
⨯
Gerardo Soriano,

Affiliation Multiple Sclerosis Unit, Department of Neurology, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain
⨯
Francisco Lacruz,

Affiliation Multiple Sclerosis Unit, Department of Neurology, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain
⨯
Maite Mendioroz

* E-mail: maitemendilab@gmail.com

Affiliations Department of Neurology, Complejo Hospitalario de Navarra, Pamplona, Navarra, Spain, Neuroepigenetics Laboratory, Navarrabiomed- Navarra Institute for Health Research (IdiSNA), Pamplona, Navarra, Spain

http://orcid.org/0000-0002-4179-5781

⨯

Vitamin D receptor gene is epigenetically altered and transcriptionally up-regulated in multiple sclerosis

Teresa Ayuso,
Patricia Aznar,
Luis Soriano,
Ander Olaskoaga,
Miren Roldán,
María Otano,
Iratxe Ajuria,
Gerardo Soriano,
Francisco Lacruz,
Maite Mendioroz

Published: March 29, 2017
https://doi.org/10.1371/journal.pone.0174726

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

DNA methylation
Is the Subject Area "DNA methylation" applicable to this article?

Thanks for your feedback.
Multiple sclerosis
Is the Subject Area "Multiple sclerosis" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Vitamin D
Is the Subject Area "Vitamin D" applicable to this article?

Thanks for your feedback.
Messenger RNA
Is the Subject Area "Messenger RNA" applicable to this article?

Thanks for your feedback.
Epigenetics
Is the Subject Area "Epigenetics" applicable to this article?

Thanks for your feedback.
Promoter regions
Is the Subject Area "Promoter regions" applicable to this article?

Thanks for your feedback.